Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes

Kazuo Nakamura, Sho ichi Yamagishi, Hisashi Adachi, Takanori Matsui, Yayoi Kurita-Nakamura, Masayoshi Takeuchi, Hiroyoshi Inoue, Tsutomu Imaizumi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We have recently found that soluble form of receptor for advanced glycation end products (sRAGE) levels are positively associated with inflammatory biomarkers and the presence of coronary artery disease (CAD) in type 2 diabetic patients. Since advanced glycation end products (AGEs) up-regulate RAGE expression and endogenous sRAGE could be generated from the cleavage of cell surface RAGE, it is conceivable that sRAGE is positively associated with circulating AGEs levels in diabetes. In this study, we examined whether sRAGE were correlated to circulating levels of AGEs and soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in patients with type 2 diabetes. Eighty-two Japanese type 2 diabetic patients underwent a complete history and physical examination, determination of blood chemistries, sRAGE, AGEs, sVCAM-1 and sICAM-1. Multiple regression analysis revealed that serum levels of AGEs and sVCAM-1 were independently correlated with sRAGE. This study demonstrated that serum levels of sRAGE were positively associated with circulating AGEs and sVCAM-1 levels in type 2 diabetic patients. Our present observations suggest sRAGE level may be elevated in response to circulating AGEs, thus being a novel marker of vascular injury in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalMicrovascular Research
Volume76
Issue number1
DOIs
Publication statusPublished - 2008 May
Externally publishedYes

Fingerprint

Vascular Cell Adhesion Molecule-1
Medical problems
Type 2 Diabetes Mellitus
Serum
Intercellular Adhesion Molecule-1
Advanced Glycosylation End Products
Advanced Glycosylation End Product-Specific Receptor
Vascular System Injuries
Biomarkers
Regression analysis
Physical Examination
Coronary Artery Disease
Blood
Up-Regulation
History
Regression Analysis

Keywords

  • AGEs
  • Atherosclerosis
  • Diabetes
  • sRAGE
  • sVCAM-1

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine

Cite this

Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes. / Nakamura, Kazuo; Yamagishi, Sho ichi; Adachi, Hisashi; Matsui, Takanori; Kurita-Nakamura, Yayoi; Takeuchi, Masayoshi; Inoue, Hiroyoshi; Imaizumi, Tsutomu.

In: Microvascular Research, Vol. 76, No. 1, 05.2008, p. 52-56.

Research output: Contribution to journalArticle

Nakamura, Kazuo ; Yamagishi, Sho ichi ; Adachi, Hisashi ; Matsui, Takanori ; Kurita-Nakamura, Yayoi ; Takeuchi, Masayoshi ; Inoue, Hiroyoshi ; Imaizumi, Tsutomu. / Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes. In: Microvascular Research. 2008 ; Vol. 76, No. 1. pp. 52-56.
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