Serum magnesium, ambulatory blood pressure, and carotid artery alteration: The ohasama study

Takanao Hashimoto, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Manami Nakashita, Shiho Terata, Taku Obara, Takuo Hirose, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.Methods sMg and ABP, monitored every 30min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used. Results Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥ 2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80mmHg), lower sMg levels (<2.2mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of >2 carotid plaques (OR, 2.14; 95% confidence interval, 1.18-3.85; P = 0.01). Conclusions Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.

Original languageEnglish
Pages (from-to)1292-1298
Number of pages7
JournalAmerican journal of hypertension
Volume23
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1
Externally publishedYes

Fingerprint

Carotid Arteries
Magnesium
Blood Pressure
Serum
Odds Ratio
Carotid Intima-Media Thickness
Phosphorus
Population
Minerals
Creatinine
Potassium
Reference Values
Cardiovascular Diseases
Logistic Models
Sodium
Regression Analysis
Confidence Intervals
Calcium
Incidence

Keywords

  • ambulatory blood pressure
  • blood pressure
  • carotid plaque
  • general population
  • hypertension
  • intima-media thickness
  • serum magnesium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Serum magnesium, ambulatory blood pressure, and carotid artery alteration : The ohasama study. / Hashimoto, Takanao; Hara, Azusa; Ohkubo, Takayoshi; Kikuya, Masahiro; Shintani, Yoriko; Metoki, Hirohito; Inoue, Ryusuke; Asayama, Kei; Kanno, Atsuhiro; Nakashita, Manami; Terata, Shiho; Obara, Taku; Hirose, Takuo; Hoshi, Haruhisa; Totsune, Kazuhito; Satoh, Hiroshi; Imai, Yutaka.

In: American journal of hypertension, Vol. 23, No. 12, 01.12.2010, p. 1292-1298.

Research output: Contribution to journalArticle

Hashimoto, T, Hara, A, Ohkubo, T, Kikuya, M, Shintani, Y, Metoki, H, Inoue, R, Asayama, K, Kanno, A, Nakashita, M, Terata, S, Obara, T, Hirose, T, Hoshi, H, Totsune, K, Satoh, H & Imai, Y 2010, 'Serum magnesium, ambulatory blood pressure, and carotid artery alteration: The ohasama study', American journal of hypertension, vol. 23, no. 12, pp. 1292-1298. https://doi.org/10.1038/ajh.2010.168
Hashimoto, Takanao ; Hara, Azusa ; Ohkubo, Takayoshi ; Kikuya, Masahiro ; Shintani, Yoriko ; Metoki, Hirohito ; Inoue, Ryusuke ; Asayama, Kei ; Kanno, Atsuhiro ; Nakashita, Manami ; Terata, Shiho ; Obara, Taku ; Hirose, Takuo ; Hoshi, Haruhisa ; Totsune, Kazuhito ; Satoh, Hiroshi ; Imai, Yutaka. / Serum magnesium, ambulatory blood pressure, and carotid artery alteration : The ohasama study. In: American journal of hypertension. 2010 ; Vol. 23, No. 12. pp. 1292-1298.
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abstract = "Background To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.Methods sMg and ABP, monitored every 30min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used. Results Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥ 2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80mmHg), lower sMg levels (<2.2mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of >2 carotid plaques (OR, 2.14; 95{\%} confidence interval, 1.18-3.85; P = 0.01). Conclusions Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.",
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T1 - Serum magnesium, ambulatory blood pressure, and carotid artery alteration

T2 - The ohasama study

AU - Hashimoto, Takanao

AU - Hara, Azusa

AU - Ohkubo, Takayoshi

AU - Kikuya, Masahiro

AU - Shintani, Yoriko

AU - Metoki, Hirohito

AU - Inoue, Ryusuke

AU - Asayama, Kei

AU - Kanno, Atsuhiro

AU - Nakashita, Manami

AU - Terata, Shiho

AU - Obara, Taku

AU - Hirose, Takuo

AU - Hoshi, Haruhisa

AU - Totsune, Kazuhito

AU - Satoh, Hiroshi

AU - Imai, Yutaka

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.Methods sMg and ABP, monitored every 30min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used. Results Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥ 2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80mmHg), lower sMg levels (<2.2mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of >2 carotid plaques (OR, 2.14; 95% confidence interval, 1.18-3.85; P = 0.01). Conclusions Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.

AB - Background To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.Methods sMg and ABP, monitored every 30min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used. Results Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥ 2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80mmHg), lower sMg levels (<2.2mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of >2 carotid plaques (OR, 2.14; 95% confidence interval, 1.18-3.85; P = 0.01). Conclusions Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.

KW - ambulatory blood pressure

KW - blood pressure

KW - carotid plaque

KW - general population

KW - hypertension

KW - intima-media thickness

KW - serum magnesium

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