Serum MIP-1α and IL-8 in septic patients

S. Fujishima, J. Sasaki, Y. Shinozawa, K. Takuma, H. Kimura, M. Suzuki, M. Kanazawa, S. Hori, N. Aikawa

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Abstract

We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.

Original languageEnglish
Pages (from-to)1169-1175
Number of pages7
JournalIntensive Care Medicine
Volume22
Issue number11
DOIs
Publication statusPublished - 1996 Jan 1

Keywords

  • Disseminated intravascular Coagulation (DIC)
  • Interleukin-8 (IL-8)
  • Macrophage inflammatory protein-1 alpha (MIP-1α)
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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  • Cite this

    Fujishima, S., Sasaki, J., Shinozawa, Y., Takuma, K., Kimura, H., Suzuki, M., Kanazawa, M., Hori, S., & Aikawa, N. (1996). Serum MIP-1α and IL-8 in septic patients. Intensive Care Medicine, 22(11), 1169-1175. https://doi.org/10.1007/BF01709331