Serum MIP-1α and IL-8 in septic patients

Seitaro Fujishima, Junichi Sasaki, Y. Shinozawa, K. Takuma, H. Kimura, M. Suzuki, M. Kanazawa, S. Hori, N. Aikawa

Research output: Contribution to journalArticle

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Abstract

We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.

Original languageEnglish
Pages (from-to)1169-1175
Number of pages7
JournalIntensive Care Medicine
Volume22
Issue number11
DOIs
Publication statusPublished - 1996

Fingerprint

Interleukin-8
Serum
Mortality
Sepsis
Healthy Volunteers
Disseminated Intravascular Coagulation
Chemokines
Renal Insufficiency
Interleukin-6
Central Nervous System

Keywords

  • Disseminated intravascular Coagulation (DIC)
  • Interleukin-8 (IL-8)
  • Macrophage inflammatory protein-1 alpha (MIP-1α)
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Fujishima, S., Sasaki, J., Shinozawa, Y., Takuma, K., Kimura, H., Suzuki, M., ... Aikawa, N. (1996). Serum MIP-1α and IL-8 in septic patients. Intensive Care Medicine, 22(11), 1169-1175. https://doi.org/10.1007/s001340050233

Serum MIP-1α and IL-8 in septic patients. / Fujishima, Seitaro; Sasaki, Junichi; Shinozawa, Y.; Takuma, K.; Kimura, H.; Suzuki, M.; Kanazawa, M.; Hori, S.; Aikawa, N.

In: Intensive Care Medicine, Vol. 22, No. 11, 1996, p. 1169-1175.

Research output: Contribution to journalArticle

Fujishima, S, Sasaki, J, Shinozawa, Y, Takuma, K, Kimura, H, Suzuki, M, Kanazawa, M, Hori, S & Aikawa, N 1996, 'Serum MIP-1α and IL-8 in septic patients', Intensive Care Medicine, vol. 22, no. 11, pp. 1169-1175. https://doi.org/10.1007/s001340050233
Fujishima, Seitaro ; Sasaki, Junichi ; Shinozawa, Y. ; Takuma, K. ; Kimura, H. ; Suzuki, M. ; Kanazawa, M. ; Hori, S. ; Aikawa, N. / Serum MIP-1α and IL-8 in septic patients. In: Intensive Care Medicine. 1996 ; Vol. 22, No. 11. pp. 1169-1175.
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