Serum MIP-1α and IL-8 in septic patients

S. Fujishima; J. Sasaki; Y. Shinozawa; K. Takuma; H. Kimura; M. Suzuki; M. Kanazawa; S. Hori; N. Aikawa

doi:10.1007/BF01709331

Serum MIP-1α and IL-8 in septic patients

S. Fujishima, J. Sasaki, Y. Shinozawa, K. Takuma, H. Kimura, M. Suzuki, M. Kanazawa, S. Hori, N. Aikawa

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.

Original language	English
Pages (from-to)	1169-1175
Number of pages	7
Journal	Intensive Care Medicine
Volume	22
Issue number	11
DOIs	https://doi.org/10.1007/BF01709331
Publication status	Published - 1996 Jan 1

Keywords

Disseminated intravascular Coagulation (DIC)
Interleukin-8 (IL-8)
Macrophage inflammatory protein-1 alpha (MIP-1α)
Sepsis

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1007/BF01709331

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title = "Serum MIP-1α and IL-8 in septic patients",

abstract = "We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.",

keywords = "Disseminated intravascular Coagulation (DIC), Interleukin-8 (IL-8), Macrophage inflammatory protein-1 alpha (MIP-1α), Sepsis",

author = "S. Fujishima and J. Sasaki and Y. Shinozawa and K. Takuma and H. Kimura and M. Suzuki and M. Kanazawa and S. Hori and N. Aikawa",

year = "1996",

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AU - Fujishima, S.

AU - Sasaki, J.

AU - Shinozawa, Y.

AU - Takuma, K.

AU - Kimura, H.

AU - Suzuki, M.

AU - Kanazawa, M.

AU - Hori, S.

AU - Aikawa, N.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.

AB - We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.

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