Abstract
We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.
| Original language | English |
|---|---|
| Pages (from-to) | 1169-1175 |
| Number of pages | 7 |
| Journal | Intensive Care Medicine |
| Volume | 22 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1996 |
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Keywords
- Disseminated intravascular Coagulation (DIC)
- Interleukin-8 (IL-8)
- Macrophage inflammatory protein-1 alpha (MIP-1α)
- Sepsis
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Serum MIP-1α and IL-8 in septic patients. / Fujishima, Seitaro; Sasaki, Junichi; Shinozawa, Y.; Takuma, K.; Kimura, H.; Suzuki, M.; Kanazawa, M.; Hori, S.; Aikawa, N.
In: Intensive Care Medicine, Vol. 22, No. 11, 1996, p. 1169-1175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum MIP-1α and IL-8 in septic patients
AU - Fujishima, Seitaro
AU - Sasaki, Junichi
AU - Shinozawa, Y.
AU - Takuma, K.
AU - Kimura, H.
AU - Suzuki, M.
AU - Kanazawa, M.
AU - Hori, S.
AU - Aikawa, N.
PY - 1996
Y1 - 1996
N2 - We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.
AB - We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p < 0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.
KW - Disseminated intravascular Coagulation (DIC)
KW - Interleukin-8 (IL-8)
KW - Macrophage inflammatory protein-1 alpha (MIP-1α)
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=0029839260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029839260&partnerID=8YFLogxK
U2 - 10.1007/s001340050233
DO - 10.1007/s001340050233
M3 - Article
C2 - 9120108
AN - SCOPUS:0029839260
VL - 22
SP - 1169
EP - 1175
JO - Intensive Care Medicine
JF - Intensive Care Medicine
SN - 0342-4642
IS - 11
ER -