Serum nitrate/nitrite concentration correlates with gastric juice nitrate/nitrite: A possible marker for mutagenesis of the proximal stomach

Hiroshi Kishikawa, Jiro Nishida, Hitoshi Ichikawa, Shogo Kaida, Takashi Matsukubo, Soichiro Miura, Tetsuo Morishita, Toshifumi Hibi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: In the normal acid-secreting stomach, luminally generated nitric oxide, which contributes to carcinogenesis in the proximal stomach, is associated with the concentration of nitrate plus nitrite (nitrate/nitrite) in gastric juice. We investigated whether the serum nitrate/nitrite concentration is associated with that of gastric juice and whether it can be used as a serum marker. Methods: Serum and gastric juice nitrate/nitrite concentration, Helicobacter pylori antibody, and gastric pH were measured in 176 patients undergoing upper endoscopy. Results: Multiple regression analysis revealed that serum nitrate/nitrite concentration was the best independent predictor of gastric juice nitrate/nitrite concentration. On single regression analysis, serum and gastric juice nitrate/nitrite concentration were significantly correlated, according to the following equation: gastric juice nitrate/nitrite concentration (μmol/l) = 3.93 - 0.54 × serum nitrate/nitrite concentration (μmol/l; correlation coefficient = 0.429, p < 0.001). In analyses confined to subjects with gastric pH less than 2.0, and in those with serum markers suggesting normal acid secretion (pepsinogen-I >30 ng/ml and negative H. pylori antibody), the serum nitrate/nitrite concentration was an independent predictor of the gastric juice nitrate/nitrite concentration (p < 0.001). Conclusion: Measuring the serum nitrate/nitrite concentration has potential in estimating the gastric juice nitrate/nitrite concentration. The serum nitrate/nitrite concentration could be useful as a marker for mutagenesis in the proximal stomach.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalDigestion
Volume84
Issue number1
DOIs
Publication statusPublished - 2011 Jul 1

Keywords

  • Biological markers
  • Carcinogenesis
  • Gastric cancer
  • Regression analysis
  • Serum nitrate/nitrite

ASJC Scopus subject areas

  • Gastroenterology

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