Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: The KOBE study

Yoshimi Kubota, A. Higashiyama, H. Imano, Daisuke Sugiyama, K. Kawamura, A. Kadota, K. Nishimura, N. Miyamatsu, Y. Miyamoto, Tomonori Okamura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Objectives: Serum polyunsaturated fatty acid (PUFA) composition reflects dietary intake and is related to risks for cardiovascular diseases. We hypothesized that serum n-3 PUFA composition, especially including long-chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with inflammatory status, which is related to increased risk for cardiovascular diseases. Subjects/Methods: We investigated the relationship between serum PUFA composition and high-sensitivity C-reactive protein (hs-CRP) levels in a cross-sectional study among 1,102 healthy men and women aged 40–74 years who reside in Kobe City. Multiple linear regression models that predict hs-CRP level were prepared to confirm the contribution of serum total n-3 PUFA, long-chain n-3 PUFA, EPA and DHA compositions after adjusting for other PUFAs and atherosclerotic risk factors. Results: The serum n-3 PUFA, particularly long-chain n-3 PUFA, compositions were inversely associated with the hs-CRP levels. The standardized regression coefficient was −0.089 (p < 0.01) for total n-3 PUFA, −0.091 (p < 0.01) for long-chain n-3 PUFA, −0.071 (p = 0.03) for EPA, and −0.068 (p = 0.04) for DHA. The n-6 PUFA compositions were also inversely associated with the hs-CRP levels (−0.169 [p < 0.01] for total n-6 PUFA and −0.159 [p < 0.01] for linoleic acid). Conclusions: The serum n-3 PUFA compositions were inversely related with the hs-CRP levels, similar associations were also observed in n-6 PUFA compositions. Our results suggest that dietary PUFA intake was inversely associated with attenuated inflammation in healthy Japanese population.

Original languageEnglish
Pages (from-to)719-728
Number of pages10
JournalJournal of Nutrition, Health and Aging
Volume19
Issue number7
DOIs
Publication statusPublished - 2015 Aug 28

Fingerprint

Omega-3 Fatty Acids
Unsaturated Fatty Acids
C-Reactive Protein
Serum
Eicosapentaenoic Acid
Docosahexaenoic Acids
Linear Models
Cardiovascular Diseases
Linoleic Acid
Cross-Sectional Studies
Inflammation

Keywords

  • hs-CRP
  • long chain n-3 polyunsaturated fatty acid
  • n-3 polyunsaturated fatty acid
  • n-6 polyunsaturated fatty acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents : The KOBE study. / Kubota, Yoshimi; Higashiyama, A.; Imano, H.; Sugiyama, Daisuke; Kawamura, K.; Kadota, A.; Nishimura, K.; Miyamatsu, N.; Miyamoto, Y.; Okamura, Tomonori.

In: Journal of Nutrition, Health and Aging, Vol. 19, No. 7, 28.08.2015, p. 719-728.

Research output: Contribution to journalArticle

Kubota, Yoshimi ; Higashiyama, A. ; Imano, H. ; Sugiyama, Daisuke ; Kawamura, K. ; Kadota, A. ; Nishimura, K. ; Miyamatsu, N. ; Miyamoto, Y. ; Okamura, Tomonori. / Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents : The KOBE study. In: Journal of Nutrition, Health and Aging. 2015 ; Vol. 19, No. 7. pp. 719-728.
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AU - Imano, H.

AU - Sugiyama, Daisuke

AU - Kawamura, K.

AU - Kadota, A.

AU - Nishimura, K.

AU - Miyamatsu, N.

AU - Miyamoto, Y.

AU - Okamura, Tomonori

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AB - Background/Objectives: Serum polyunsaturated fatty acid (PUFA) composition reflects dietary intake and is related to risks for cardiovascular diseases. We hypothesized that serum n-3 PUFA composition, especially including long-chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with inflammatory status, which is related to increased risk for cardiovascular diseases. Subjects/Methods: We investigated the relationship between serum PUFA composition and high-sensitivity C-reactive protein (hs-CRP) levels in a cross-sectional study among 1,102 healthy men and women aged 40–74 years who reside in Kobe City. Multiple linear regression models that predict hs-CRP level were prepared to confirm the contribution of serum total n-3 PUFA, long-chain n-3 PUFA, EPA and DHA compositions after adjusting for other PUFAs and atherosclerotic risk factors. Results: The serum n-3 PUFA, particularly long-chain n-3 PUFA, compositions were inversely associated with the hs-CRP levels. The standardized regression coefficient was −0.089 (p < 0.01) for total n-3 PUFA, −0.091 (p < 0.01) for long-chain n-3 PUFA, −0.071 (p = 0.03) for EPA, and −0.068 (p = 0.04) for DHA. The n-6 PUFA compositions were also inversely associated with the hs-CRP levels (−0.169 [p < 0.01] for total n-6 PUFA and −0.159 [p < 0.01] for linoleic acid). Conclusions: The serum n-3 PUFA compositions were inversely related with the hs-CRP levels, similar associations were also observed in n-6 PUFA compositions. Our results suggest that dietary PUFA intake was inversely associated with attenuated inflammation in healthy Japanese population.

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KW - n-6 polyunsaturated fatty acid

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