Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents

The KOBE study

Yoshimi Kubota, A. Higashiyama, H. Imano, Daisuke Sugiyama, K. Kawamura, A. Kadota, K. Nishimura, N. Miyamatsu, Y. Miyamoto, Tomonori Okamura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/Objectives: Serum polyunsaturated fatty acid (PUFA) composition reflects dietary intake and is related to risks for cardiovascular diseases. We hypothesized that serum n-3 PUFA composition, especially including long-chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with inflammatory status, which is related to increased risk for cardiovascular diseases. Subjects/Methods: We investigated the relationship between serum PUFA composition and high-sensitivity C-reactive protein (hs-CRP) levels in a cross-sectional study among 1,102 healthy men and women aged 40–74 years who reside in Kobe City. Multiple linear regression models that predict hs-CRP level were prepared to confirm the contribution of serum total n-3 PUFA, long-chain n-3 PUFA, EPA and DHA compositions after adjusting for other PUFAs and atherosclerotic risk factors. Results: The serum n-3 PUFA, particularly long-chain n-3 PUFA, compositions were inversely associated with the hs-CRP levels. The standardized regression coefficient was −0.089 (p < 0.01) for total n-3 PUFA, −0.091 (p < 0.01) for long-chain n-3 PUFA, −0.071 (p = 0.03) for EPA, and −0.068 (p = 0.04) for DHA. The n-6 PUFA compositions were also inversely associated with the hs-CRP levels (−0.169 [p < 0.01] for total n-6 PUFA and −0.159 [p < 0.01] for linoleic acid). Conclusions: The serum n-3 PUFA compositions were inversely related with the hs-CRP levels, similar associations were also observed in n-6 PUFA compositions. Our results suggest that dietary PUFA intake was inversely associated with attenuated inflammation in healthy Japanese population.

Original languageEnglish
Pages (from-to)719-728
Number of pages10
JournalJournal of Nutrition, Health and Aging
Volume19
Issue number7
DOIs
Publication statusPublished - 2015 Aug 28

Fingerprint

Omega-3 Fatty Acids
Unsaturated Fatty Acids
C-Reactive Protein
Serum
Eicosapentaenoic Acid
Docosahexaenoic Acids
Linear Models
Cardiovascular Diseases
Linoleic Acid
Cross-Sectional Studies
Inflammation

Keywords

  • hs-CRP
  • long chain n-3 polyunsaturated fatty acid
  • n-3 polyunsaturated fatty acid
  • n-6 polyunsaturated fatty acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents : The KOBE study. / Kubota, Yoshimi; Higashiyama, A.; Imano, H.; Sugiyama, Daisuke; Kawamura, K.; Kadota, A.; Nishimura, K.; Miyamatsu, N.; Miyamoto, Y.; Okamura, Tomonori.

In: Journal of Nutrition, Health and Aging, Vol. 19, No. 7, 28.08.2015, p. 719-728.

Research output: Contribution to journalArticle

Kubota, Yoshimi ; Higashiyama, A. ; Imano, H. ; Sugiyama, Daisuke ; Kawamura, K. ; Kadota, A. ; Nishimura, K. ; Miyamatsu, N. ; Miyamoto, Y. ; Okamura, Tomonori. / Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents : The KOBE study. In: Journal of Nutrition, Health and Aging. 2015 ; Vol. 19, No. 7. pp. 719-728.
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AU - Sugiyama, Daisuke

AU - Kawamura, K.

AU - Kadota, A.

AU - Nishimura, K.

AU - Miyamatsu, N.

AU - Miyamoto, Y.

AU - Okamura, Tomonori

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KW - n-6 polyunsaturated fatty acid

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