Serum type III procollagen peptide: Indicator for pulmonary fibrosis I. A tool for early detection of pulmonary fibrosis as a complication in cancer therapy

Isao Okazaki, Koji Miura, Yumiko Kobayashi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To clarify whether serum type III procollagen peptide can reflect degree of pulmonary fibrosis and is useful for the early detection of pulmonary fibrosis seen as a complication of cancer therapy, 24 cancer patients were investigated before and after radiation therapy or treatment with anti-cancer drugs. The serum peptide levels in 68 healthy adults was 8.6 ± 2.4 ng/ml (mean ± SD). Before cancer therapy the serum peptide levels in 15 cancer patients without detectab!e liver dysfunction were within normal range. After cancer therapy thirteen cancer patients with complicating pulmonary fibrosis revealed 24.3 ± 8.0 in serum, while the remaining 11 cases without complication of pulmonary fibrosis showed lower values of 16.1 ± 2.5 with statistical significance (p<0.01). There was no correlation between serum peptide level and degree of pulmonary fibrosis. However, the cases showing high values revealed interstitial pneumonitis followed by rapid progressive pulmonary fibrosis caused by radiation therapy or treatment with anti-cancer drugs. These results indicate that this method is useful for detecting the complication of progressive interstitial pulmonary fibrosis at an early stage.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalThe Keio journal of medicine
Volume35
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

Collagen Type III
Pulmonary Fibrosis
Peptides
Serum
Neoplasms
Therapeutics
Radiotherapy
Interstitial Lung Diseases
Pharmaceutical Preparations
Liver Diseases
Reference Values

Keywords

  • drug-induced
  • fibrogenic marker
  • pulmonary fibrosis
  • radiation-induced pulmonary fibrosis
  • type III procollagen peptide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Serum type III procollagen peptide: Indicator for pulmonary fibrosis I. A tool for early detection of pulmonary fibrosis as a complication in cancer therapy",
abstract = "To clarify whether serum type III procollagen peptide can reflect degree of pulmonary fibrosis and is useful for the early detection of pulmonary fibrosis seen as a complication of cancer therapy, 24 cancer patients were investigated before and after radiation therapy or treatment with anti-cancer drugs. The serum peptide levels in 68 healthy adults was 8.6 ± 2.4 ng/ml (mean ± SD). Before cancer therapy the serum peptide levels in 15 cancer patients without detectab!e liver dysfunction were within normal range. After cancer therapy thirteen cancer patients with complicating pulmonary fibrosis revealed 24.3 ± 8.0 in serum, while the remaining 11 cases without complication of pulmonary fibrosis showed lower values of 16.1 ± 2.5 with statistical significance (p<0.01). There was no correlation between serum peptide level and degree of pulmonary fibrosis. However, the cases showing high values revealed interstitial pneumonitis followed by rapid progressive pulmonary fibrosis caused by radiation therapy or treatment with anti-cancer drugs. These results indicate that this method is useful for detecting the complication of progressive interstitial pulmonary fibrosis at an early stage.",
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author = "Isao Okazaki and Koji Miura and Yumiko Kobayashi",
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AU - Miura, Koji

AU - Kobayashi, Yumiko

PY - 1986

Y1 - 1986

N2 - To clarify whether serum type III procollagen peptide can reflect degree of pulmonary fibrosis and is useful for the early detection of pulmonary fibrosis seen as a complication of cancer therapy, 24 cancer patients were investigated before and after radiation therapy or treatment with anti-cancer drugs. The serum peptide levels in 68 healthy adults was 8.6 ± 2.4 ng/ml (mean ± SD). Before cancer therapy the serum peptide levels in 15 cancer patients without detectab!e liver dysfunction were within normal range. After cancer therapy thirteen cancer patients with complicating pulmonary fibrosis revealed 24.3 ± 8.0 in serum, while the remaining 11 cases without complication of pulmonary fibrosis showed lower values of 16.1 ± 2.5 with statistical significance (p<0.01). There was no correlation between serum peptide level and degree of pulmonary fibrosis. However, the cases showing high values revealed interstitial pneumonitis followed by rapid progressive pulmonary fibrosis caused by radiation therapy or treatment with anti-cancer drugs. These results indicate that this method is useful for detecting the complication of progressive interstitial pulmonary fibrosis at an early stage.

AB - To clarify whether serum type III procollagen peptide can reflect degree of pulmonary fibrosis and is useful for the early detection of pulmonary fibrosis seen as a complication of cancer therapy, 24 cancer patients were investigated before and after radiation therapy or treatment with anti-cancer drugs. The serum peptide levels in 68 healthy adults was 8.6 ± 2.4 ng/ml (mean ± SD). Before cancer therapy the serum peptide levels in 15 cancer patients without detectab!e liver dysfunction were within normal range. After cancer therapy thirteen cancer patients with complicating pulmonary fibrosis revealed 24.3 ± 8.0 in serum, while the remaining 11 cases without complication of pulmonary fibrosis showed lower values of 16.1 ± 2.5 with statistical significance (p<0.01). There was no correlation between serum peptide level and degree of pulmonary fibrosis. However, the cases showing high values revealed interstitial pneumonitis followed by rapid progressive pulmonary fibrosis caused by radiation therapy or treatment with anti-cancer drugs. These results indicate that this method is useful for detecting the complication of progressive interstitial pulmonary fibrosis at an early stage.

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