Serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 as a marker of progenitor/ biliary features in hepatocellular carcinoma

Nobuharu Tamaki, Atsushi Kuno, Atsushi Matsuda, Hanako Tsujikawa, Ken Yamazaki, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Masaaki Korenaga, Masashi Mizokami, Masayuki Kurosaki, Michiie Sakamoto, Hisashi Narimatsu, Namiki Izumi

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Abstract

Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-sialylated MUC1), which is a novel biliary marker, as a marker of HCC with hepatic progenitor cell (HPC)/biliary features and of prognosis. A total of 144 consecutive patients who underwent complete radiofrequency ablation of primary HCC were enrolled. A serum WFAsialylated MUC1 level of 900 μL/mL was determined as the optimal cutoff value for prediction of immunohistochemical staining for HPC/biliary features [sialylated MUC1 and cytokeratin 19 (CK19)]. Positive staining rate of sialylated MUC1 and CK19 was significantly higher in patients with WFAsialylated MUC1 ≥900 than those with WFA-sialylated MUC1 <900. Furthermore, cumulative incidence of HCC recurrence was significantly higher in patients with WFA-sialylated MUC1 ≥900 and on multivariate analysis, serum WFA-sialylated MUC1 levels was an independent predictor of HCC recurrence. These results revealed that serum WFA-sialylated MUC1 was associated with histological feature of HCC and recurrence after curative therapy and it could be a novel marker of HPC/biliary features in HCC and of prognosis.

Original languageEnglish
Article number224
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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    Tamaki, N., Kuno, A., Matsuda, A., Tsujikawa, H., Yamazaki, K., Yasui, Y., Tsuchiya, K., Nakanishi, H., Itakura, J., Korenaga, M., Mizokami, M., Kurosaki, M., Sakamoto, M., Narimatsu, H., & Izumi, N. (2017). Serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 as a marker of progenitor/ biliary features in hepatocellular carcinoma. Scientific Reports, 7(1), [224]. https://doi.org/10.1038/s41598-017-00357-8