Severe headache in a patient with meningioma showing extensive dural tail correlates with IgG4-positive plasma cells and eosinophils: A case report and review of literature

Yuki Kuranari, Ryota Tamura, Shuji Mikami, Kentaro Ohara, Masahiro Toda, Kazunari Yoshida

Research output: Contribution to journalArticle

Abstract

Background: Meningiomas originate from meningothelial cells of the arachnoid membrane. Few cases of meningioma with infiltration of inflammatory cells, such as lymphocytes and plasma cells, have been reported, and the mechanisms underlying meningioma-induced inflammatory reactions have not been fully elucidated. Case Description: In this study, we report an extremely rare case of meningioma with infiltration of both IgG4-positive plasma cells and eosinophils showing extensive dural tail and reactive inflammation of the surrounding arachnoid tissue. The main clinical manifestation was a severe headache, which was improved by surgical excision of the tumor. Conclusion: Only 8 cases of meningioma with IgG4-positive plasma cells have been reported, and only one case exhibited eosinophil infiltration. IgG4-related inflammatory response might mediate inflammation in surrounding tissue, resulting in thickening of the dura adjacent to a meningioma and severe headache. The mechanisms underlying inflammation by meningiomas require further investigation.

Original languageEnglish
Article number202
JournalSurgical Neurology International
Volume9
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • Eosinophil
  • IgG4
  • hypertrophic pachymeningitis
  • meningioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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