Severe oral infection due to Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia

Yuko Ishihara, Junya Kanda, Kaori Tanaka, Hirofumi Nakano, Tomotaka Ugai, Hidenori Wada, Ryoko Yamasaki, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako-Saito, Shun ichi Kimura, Misato Kikuchi, Hideki Nakasone, Rie Yamazaki, Shinichi Kako, Junji Nishida, Kunitomo Watanabe, Yoshinobu Kanda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of severe oral infection with a high fever due to Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia. The patient did not improve on treatment with meropenem, clindamycin, or vancomycin until neutrophil recovery. Since L. rhamnosus GG is used in dairy products, and the patient ingested dairy products daily before starting chemotherapy, we suspected an association between the ingestion of dairy products and the development of infection. Pulsed-field gel electrophoresis using two different restriction enzymes showed that the strain isolated from the patient was identical to the L. rhamnosus GG strain isolated from dairy products and ATCC #53103. This was confirmed by a PCR assay with species-specific L. rhamnosus GG primers. Since Lactobacillus infection, particularly L. rhamnosus infection, can be fatal in immunocompromised hosts, we should consider Lactobacillus as a causative organism when Gram-positive rods are detected during treatment with broad-spectrum antibiotics and vancomycin. The causal association between the ingestion of dairy products containing Lactobacillus and Lactobacillus infection in immunocompromised hosts warrants further study.

Original languageEnglish
Pages (from-to)607-610
Number of pages4
JournalInternational Journal of Hematology
Volume100
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Lactobacillus rhamnosus
Induction Chemotherapy
Acute Myeloid Leukemia
Dairy Products
Lactobacillus
Infection
meropenem
Immunocompromised Host
Vancomycin
Eating
Gram-Positive Rods
Clindamycin
Pulsed Field Gel Electrophoresis
Neutrophils
Fever
Anti-Bacterial Agents
Drug Therapy
Polymerase Chain Reaction

Keywords

  • Acute myeloid leukemia
  • Lactobacillus rhamnosus
  • Neutropenic fever
  • Oral infection

ASJC Scopus subject areas

  • Hematology

Cite this

Severe oral infection due to Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia. / Ishihara, Yuko; Kanda, Junya; Tanaka, Kaori; Nakano, Hirofumi; Ugai, Tomotaka; Wada, Hidenori; Yamasaki, Ryoko; Kawamura, Koji; Sakamoto, Kana; Ashizawa, Masahiro; Sato, Miki; Terasako-Saito, Kiriko; Kimura, Shun ichi; Kikuchi, Misato; Nakasone, Hideki; Yamazaki, Rie; Kako, Shinichi; Nishida, Junji; Watanabe, Kunitomo; Kanda, Yoshinobu.

In: International Journal of Hematology, Vol. 100, No. 6, 01.01.2014, p. 607-610.

Research output: Contribution to journalArticle

Ishihara, Y, Kanda, J, Tanaka, K, Nakano, H, Ugai, T, Wada, H, Yamasaki, R, Kawamura, K, Sakamoto, K, Ashizawa, M, Sato, M, Terasako-Saito, K, Kimura, SI, Kikuchi, M, Nakasone, H, Yamazaki, R, Kako, S, Nishida, J, Watanabe, K & Kanda, Y 2014, 'Severe oral infection due to Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia', International Journal of Hematology, vol. 100, no. 6, pp. 607-610. https://doi.org/10.1007/s12185-014-1650-7
Ishihara, Yuko ; Kanda, Junya ; Tanaka, Kaori ; Nakano, Hirofumi ; Ugai, Tomotaka ; Wada, Hidenori ; Yamasaki, Ryoko ; Kawamura, Koji ; Sakamoto, Kana ; Ashizawa, Masahiro ; Sato, Miki ; Terasako-Saito, Kiriko ; Kimura, Shun ichi ; Kikuchi, Misato ; Nakasone, Hideki ; Yamazaki, Rie ; Kako, Shinichi ; Nishida, Junji ; Watanabe, Kunitomo ; Kanda, Yoshinobu. / Severe oral infection due to Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia. In: International Journal of Hematology. 2014 ; Vol. 100, No. 6. pp. 607-610.
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