Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality

Nutritional Support Working Group of the Asian Pacific Bone Marrow Transplantation, S. Kohashi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Patients after allogeneic hematopoietic SCT (HSCT) are at risk of malnutrition. To assess the impact of malnutrition after allogeneic HSCT on transplant outcomes, we conducted a retrospective study. Adult patients who received allogeneic HSCT from 2000 to 2009 for standard-risk leukemia and achieved disease-free survival up to 3 months after allogeneic HSCT were included. From participating centers, 145 patients were enrolled. Median age was 46 years (19-68). Patients were classified based on weight loss during 3 months after allogeneic HSCT as follows: normal group (weight loss <5%, n=53), mild malnutrition group (5%≤weight loss<10%, n=47), severe malnutrition group (10% ≤weight loss, n=45). The cumulative incidences of 2-year nonrelapse mortality (NRM) were 3.8% in the normal group, 8.5% in the mild malnutrition group and 27.3% in the severe malnutrition group. The probabilities of a 2-year OS were 73.2% in the normal group, 74.5% in the mild malnutrition group and 55.3% in the severe malnutrition group. In multivariate analysis, severe malnutrition was associated with an increased risk of NRM and a worse OS. In conclusion, weight loss ≥10% was associated with a worse clinical outcome. Prospective studies that identify patients at risk of malnutrition and intervention by a nutritional support team are warranted.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalBone Marrow Transplantation
Volume50
Issue number1
DOIs
Publication statusPublished - 2015 Jan 10

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Malnutrition
Weight Loss
Mortality
Nutritional Support
Disease-Free Survival
Leukemia
Multivariate Analysis
Retrospective Studies
Prospective Studies
Transplants
Incidence

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality. / Nutritional Support Working Group of the Asian Pacific Bone Marrow Transplantation; Kohashi, S.

In: Bone Marrow Transplantation, Vol. 50, No. 1, 10.01.2015, p. 100-105.

Research output: Contribution to journalArticle

Nutritional Support Working Group of the Asian Pacific Bone Marrow Transplantation & Kohashi, S 2015, 'Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality', Bone Marrow Transplantation, vol. 50, no. 1, pp. 100-105. https://doi.org/10.1038/bmt.2014.228
Nutritional Support Working Group of the Asian Pacific Bone Marrow Transplantation ; Kohashi, S. / Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality. In: Bone Marrow Transplantation. 2015 ; Vol. 50, No. 1. pp. 100-105.
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abstract = "Patients after allogeneic hematopoietic SCT (HSCT) are at risk of malnutrition. To assess the impact of malnutrition after allogeneic HSCT on transplant outcomes, we conducted a retrospective study. Adult patients who received allogeneic HSCT from 2000 to 2009 for standard-risk leukemia and achieved disease-free survival up to 3 months after allogeneic HSCT were included. From participating centers, 145 patients were enrolled. Median age was 46 years (19-68). Patients were classified based on weight loss during 3 months after allogeneic HSCT as follows: normal group (weight loss <5{\%}, n=53), mild malnutrition group (5{\%}≤weight loss<10{\%}, n=47), severe malnutrition group (10{\%} ≤weight loss, n=45). The cumulative incidences of 2-year nonrelapse mortality (NRM) were 3.8{\%} in the normal group, 8.5{\%} in the mild malnutrition group and 27.3{\%} in the severe malnutrition group. The probabilities of a 2-year OS were 73.2{\%} in the normal group, 74.5{\%} in the mild malnutrition group and 55.3{\%} in the severe malnutrition group. In multivariate analysis, severe malnutrition was associated with an increased risk of NRM and a worse OS. In conclusion, weight loss ≥10{\%} was associated with a worse clinical outcome. Prospective studies that identify patients at risk of malnutrition and intervention by a nutritional support team are warranted.",
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