Severity of delirium in the ICU is associated with short term cognitive impairment. A prospective cohort study

Hideaki Sakuramoto, Jesmin Subrina, Takeshi Unoki, Taro Mizutani, Hiroko Komatsu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: To examine the hypothesis that severity of delirium in the intensive care unit (ICU) is positively associated with cognitive impairment at the time of hospital discharge. Design: A prospective cohort study. Setting: Adult medical and surgical ICU of a tertiary-care teaching hospital in Japan in ICU patients who were enrolled and admitted for more than 48. hours. Methods: Severity of delirium was represented as a score of the Intensive Care Delirium Screening Checklist (ICDSC) during the patients' stay in the ICU under the assumption that higher ICDSC score indicated severe delirium. After discharge from the ICU, the patients were followed up for cognitive impairment using the Mini-Mental State Examination (MMSE). Results: Of the 79 patients enrolled, 50 (63.3%) developed delirium during their stay in the ICU. Patients who developed delirium had higher rates of cognitive impairment (28.0% vs. 3.4%, p=. 0.03). After adjusting for covariates, the averaged ICDSC score during the ICU stay indicated a positive association between severity of delirium and cognitive impairment at the time of hospital discharge (adjusted odds ratio (OR) 1.6; 95% confidential interval (CI), 1.02-2.54; p=. 0.041). Conclusions: Our findings indicate that severity of delirium during ICU stay may be associated with cognitive impairment at the time of discharge from the hospital in ICU survivors.

Original languageEnglish
Pages (from-to)250-257
Number of pages8
JournalIntensive and Critical Care Nursing
Volume31
Issue number4
DOIs
Publication statusPublished - 2015 Aug 1

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Delirium
Intensive Care Units
Cohort Studies
Prospective Studies
Critical Care
Checklist
Cognitive Dysfunction
Tertiary Healthcare
Teaching Hospitals
Survivors
Japan
Odds Ratio

Keywords

  • Cognitive impairment
  • Critical illness
  • Delirium
  • Intensive Care Delirium Screening Checklists

ASJC Scopus subject areas

  • Critical Care

Cite this

Severity of delirium in the ICU is associated with short term cognitive impairment. A prospective cohort study. / Sakuramoto, Hideaki; Subrina, Jesmin; Unoki, Takeshi; Mizutani, Taro; Komatsu, Hiroko.

In: Intensive and Critical Care Nursing, Vol. 31, No. 4, 01.08.2015, p. 250-257.

Research output: Contribution to journalArticle

Sakuramoto, Hideaki ; Subrina, Jesmin ; Unoki, Takeshi ; Mizutani, Taro ; Komatsu, Hiroko. / Severity of delirium in the ICU is associated with short term cognitive impairment. A prospective cohort study. In: Intensive and Critical Care Nursing. 2015 ; Vol. 31, No. 4. pp. 250-257.
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