Sex differences in cognitive and symptom profiles in children with high functioning autism spectrum disorders

Hirokazu Kumazaki, Taro Muramatsu, Hirotaka Kosaka, Takashi X. Fujisawa, Kazuhiko Iwata, Akemi Tokoda, Kenji Tsuchiya, Masaru Mimura

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Although a small number of studies have investigated sex differences in the associated features of high-functioning autism spectrum disorders (HFASDs), they have failed to provide consistent findings. We sought to examine sex differences in 5-9-year-old females and males with HFASDs within a narrow range of ages before adolescence in order to identify the noticeable autistic profile of females compared to males. Using the Japanese version of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III) and the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), 20 females with HFASDs were compared with 26 males with HFASDs. Although females and males with HFASDs share similar cognitive profiles in WISC-III, females demonstrated a different symptom profile from males in CARS-TV. Although the female subjects scored significantly lower than the male subjects on "Body Use," "Object Use," and "Activity Level," female subjects scored significantly higher than males on "Taste, Smell, and Touch Response and Use" in the CARS-TV. This finding can be useful for the early identification of females with HFASDs who have typically been underdiagnosed. Future research should focus on elucidating the possible behavioral, neurological, and genetic links to these sex differences.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalResearch in Autism Spectrum Disorders
Publication statusPublished - 2015 May


  • Before adolescence
  • High functioning autism spectrum disorders
  • Narrow age range
  • Sex differences
  • Taste Smell Touch Response and Use

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Psychiatry and Mental health


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