Shear-induced structural transitions of peptide amphiphile

Atsushi Hotta, Tomoko Shimada, Matthew Tirrell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel method to construct hierarchical supramolecular structures in the designed peptide amphiphile solution was introduced. By simply shaking the solution at a certain frequency, the viscosity of the solution dramatically increased due to the conformational transitions and the construction of worm-like micelles, eventually causing networking of the nano-fibers made of peptide amphiphiles. The result implies that the new peptide amphiphiles undergo "hierarchical multi-scale structural transitions" ranging from a molecular-scale conformational transition, through nano-scale fibril formations, to macro-scale gelation, all caused by mechanical shear at a certain frequency. The transition was measured by Dynamic Mechanical Analysis (DMA), Circular Dichroism (CD) and cryogenic Transmission Electron Microscopy (cryo-TEM).

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages3933-3934
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Fingerprint

Amphiphiles
Peptides
Dynamic mechanical analysis
Gelation
Micelles
Cryogenics
Macros
Viscosity
Transmission electron microscopy
Fibers

Keywords

  • Hierarchical structural transitions
  • Peptide amphiphiles

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hotta, A., Shimada, T., & Tirrell, M. (2006). Shear-induced structural transitions of peptide amphiphile. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 3933-3934)

Shear-induced structural transitions of peptide amphiphile. / Hotta, Atsushi; Shimada, Tomoko; Tirrell, Matthew.

Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 3933-3934.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hotta, A, Shimada, T & Tirrell, M 2006, Shear-induced structural transitions of peptide amphiphile. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 3933-3934, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 06/9/20.
Hotta A, Shimada T, Tirrell M. Shear-induced structural transitions of peptide amphiphile. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 3933-3934
Hotta, Atsushi ; Shimada, Tomoko ; Tirrell, Matthew. / Shear-induced structural transitions of peptide amphiphile. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 3933-3934
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