Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters

H. Saito; H. Ebinuma; M. Takahashi; K. Atsukawa; T. Ohishi; H. Ishii; Y. Kiryu; N. Inagaki; K. Tsukada; Y. Miyamoto; Y. Yonei; T. Morishita; S. Tanaka; S. Miyaguchi; K. Tsuchimoto; N. Kawamura; Y. Oda; K. Suzuki; S. Kato; H. Komatsu; M. Yoshioka; A. Shibuya; K. Ishii; K. Kashiwazaki; E. Sekizuka; T. Yoshida

Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters

H. Saito, H. Ebinuma, M. Takahashi, K. Atsukawa, T. Ohishi, H. Ishii, Y. Kiryu, N. Inagaki, K. Tsukada, Y. Miyamoto, Y. Yonei, T. Morishita, S. Tanaka, S. Miyaguchi, K. Tsuchimoto, N. Kawamura, Y. Oda, K. Suzuki, S. Kato, H. KomatsuM. Yoshioka, A. Shibuya, K. Ishii, K. Kashiwazaki, E. Sekizuka, T. Yoshida

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.

Original language	English
Pages (from-to)	115-128
Number of pages	14
Journal	International Journal of Immunotherapy
Volume	14
Issue number	2
Publication status	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Saito, H., Ebinuma, H., Takahashi, M., Atsukawa, K., Ohishi, T., Ishii, H., Kiryu, Y., Inagaki, N., Tsukada, K., Miyamoto, Y., Yonei, Y., Morishita, T., Tanaka, S., Miyaguchi, S., Tsuchimoto, K., Kawamura, N., Oda, Y., Suzuki, K., Kato, S., ... Yoshida, T. (1998). Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters. International Journal of Immunotherapy, 14(2), 115-128.

Saito, H, Ebinuma, H, Takahashi, M, Atsukawa, K, Ohishi, T, Ishii, H, Kiryu, Y, Inagaki, N, Tsukada, K, Miyamoto, Y, Yonei, Y, Morishita, T, Tanaka, S, Miyaguchi, S, Tsuchimoto, K, Kawamura, N, Oda, Y, Suzuki, K, Kato, S, Komatsu, H, Yoshioka, M, Shibuya, A, Ishii, K, Kashiwazaki, K, Sekizuka, E & Yoshida, T 1998, 'Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters', International Journal of Immunotherapy, vol. 14, no. 2, pp. 115-128.

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title = "Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters",

abstract = "Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.",

author = "H. Saito and H. Ebinuma and M. Takahashi and K. Atsukawa and T. Ohishi and H. Ishii and Y. Kiryu and N. Inagaki and K. Tsukada and Y. Miyamoto and Y. Yonei and T. Morishita and S. Tanaka and S. Miyaguchi and K. Tsuchimoto and N. Kawamura and Y. Oda and K. Suzuki and S. Kato and H. Komatsu and M. Yoshioka and A. Shibuya and K. Ishii and K. Kashiwazaki and E. Sekizuka and T. Yoshida",

year = "1998",

language = "English",

volume = "14",

pages = "115--128",

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T1 - Short-course of interferon-β for the treatment of chronic hepatitis C

T2 - A multicenter trial for evaluating host immunological parameters

AU - Saito, H.

AU - Ebinuma, H.

AU - Takahashi, M.

AU - Atsukawa, K.

AU - Ohishi, T.

AU - Ishii, H.

AU - Kiryu, Y.

AU - Inagaki, N.

AU - Tsukada, K.

AU - Miyamoto, Y.

AU - Yonei, Y.

AU - Morishita, T.

AU - Tanaka, S.

AU - Miyaguchi, S.

AU - Tsuchimoto, K.

AU - Kawamura, N.

AU - Oda, Y.

AU - Suzuki, K.

AU - Kato, S.

AU - Komatsu, H.

AU - Yoshioka, M.

AU - Shibuya, A.

AU - Ishii, K.

AU - Kashiwazaki, K.

AU - Sekizuka, E.

AU - Yoshida, T.

PY - 1998

Y1 - 1998

N2 - Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.

AB - Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.

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Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters

Abstract

ASJC Scopus subject areas

UN SDGs

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