Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.
|Number of pages||14|
|Journal||International Journal of Immunotherapy|
|Publication status||Published - 1998 Jan 1|
ASJC Scopus subject areas
- Immunology and Allergy