Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters

H. Saito, Hirotoshi Ebinuma, M. Takahashi, K. Atsukawa, T. Ohishi, H. Ishii, Y. Kiryu, N. Inagaki, K. Tsukada, Y. Miyamoto, Y. Yonei, T. Morishita, S. Tanaka, S. Miyaguchi, K. Tsuchimoto, N. Kawamura, Y. Oda, K. Suzuki, S. Kato, H. KomatsuM. Yoshioka, A. Shibuya, K. Ishii, K. Kashiwazaki, E. Sekizuka, T. Yoshida

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3 Citations (Scopus)

Abstract

Host immunological parameters have not been evaluated in the response to IFN-β treatment for chronic hepatitis C. In this study, two different treatment regimens of IFN-β for chronic hepatitis C were evaluated and serum hepatitis C virus RNA levels were quantified by multicyclic reverse transcription-polymerase chain reaction. In addition, two host immunological parameters were assayed during treatment. One hundred and fifteen patients with chronic hepatitis C received 6 million units of IFN-β daily for 6 weeks or daily for 2 weeks, followed by twice a week for 14 weeks (total 16 weeks) intravenously. The efficacy of treatment was significantly correlated with initial viral load, which was confirmed by multivariate analysis. No correlation was noted between response to therapy and host immunological parameters. These findings suggest that initial hepatitis C virus levels are one of the important factors in determining the response to IFN-β.

Original languageEnglish
Pages (from-to)115-128
Number of pages14
JournalInternational Journal of Immunotherapy
Volume14
Issue number2
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Saito, H., Ebinuma, H., Takahashi, M., Atsukawa, K., Ohishi, T., Ishii, H., Kiryu, Y., Inagaki, N., Tsukada, K., Miyamoto, Y., Yonei, Y., Morishita, T., Tanaka, S., Miyaguchi, S., Tsuchimoto, K., Kawamura, N., Oda, Y., Suzuki, K., Kato, S., ... Yoshida, T. (1998). Short-course of interferon-β for the treatment of chronic hepatitis C: A multicenter trial for evaluating host immunological parameters. International Journal of Immunotherapy, 14(2), 115-128.