Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin

Jianing Zhang, Jun Nakayama, Chikara Ohyama, Masami Suzuki, Atsushi Suzuki, Minoru Fukuda, Michiko N. Fukuda

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Endothelial carbohydrate binding proteins, E- and P-selectins, are thought to mediate sialyl Lewis A/X-dependent hematogenous cancer metastasis. We tested this hypothesis using sialyl Lewis X-dependent B16 melanoma lung targeting and its inhibition with selectin ligand mimicry peptide, IELLQAR. In E/P-selectin doubly deficient mutant mice, sialyl Lewis X-expressing B16 melanoma cells colonized the lung, and IELLQAR inhibited this colonization. However, tumors grown in E/P-selectin-deficient mice were significantly smaller than those grown in wild-type mice. These results indicate that the IELLQAR peptide receptor expressed in the lung vasculature plays a major role in sialyl Lewis X-dependent cancer cells targeting to the lung.

Original languageEnglish
Pages (from-to)4194-4198
Number of pages5
JournalCancer Research
Volume62
Issue number15
Publication statusPublished - 2002 Aug 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zhang, J., Nakayama, J., Ohyama, C., Suzuki, M., Suzuki, A., Fukuda, M., & Fukuda, M. N. (2002). Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Research, 62(15), 4194-4198.