Signet-ring cell carcinoid: a primary hepatic carcinoid tumor with cytoplasmic inclusions comprising of aggregates of keratin

Kazunori Aoki, Michiie Sakamoto, Kiyoshi Mukai, Tomoo Kosuge, Tadatoshi Takayama, Setsuo Hirohashi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A case of primary hepatic carcinoid tumor was recently encountered, which was argyrophil and showed positive reactions to serotonin, gastrin and pancreatic peptide in an immunohistochemical hormonal study. The tumor had unusual morphologic features. The neoplastic cells had a signetring cell appearance, similar to the signet-ring cells normally seen in mucin-producing adenocarcinoma. Ultrastructural and immunohistochemical studies revealed the formation of the signetring cells to have been caused by the presence of cytoplasmic inclusions consisting of cytoker- atins. Further investigation, using eight monoclonal antibodies recognizing cytokeratins of different molecular weights, showed the accumulated cytokeratins to be of low and medium molecular weights. The morphologic observations in this unusual case of hepatic carcinoid tumor are described and reported cases with similar features, for which we propose the term “signetring cell carcinoid,” are reviewed.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalJapanese journal of clinical oncology
Volume22
Issue number1
DOIs
Publication statusPublished - 1992 Feb
Externally publishedYes

Keywords

  • Cytokeratin
  • Inclusion
  • Liver
  • Signet-ring cell carcinoid

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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