Signet-ring cell carcinoma of the ampulla of Vater: Report of a case

Tomotaka Akatsu, Koichi Aiura, Shin Takahashi, Kaori Kameyama, Masaki Kitajima, Yuukou Kitagawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is uncommon, and only 13 cases have been previously described. We herein report a rare case of a 43-year-old woman with SRCC in the ampulla of Vater. Although this histologic type of cancer generally predicts a poor prognosis elsewhere in the gastrointestinal tract, the present patient has survived with no evidence of recurrence for 7.5 years. The patient was hospitalized for pruritus and jaundice. She underwent a pancreaticoduodenectomy with an extended lymphadenectomy for ampullary carcinoma. This neoplasm was classified as AcdbBi, 2.0 × 1.8 cm, ulcerative type, Panc0, Du2, T 2N0M(-), Stage II according to the Japanese Classification on Cancer of the Biliary Tract. Unfortunately, previous reports of ampullary SRCC have been limited to short-term follow-ups with a median period of only 12 months (range, 6-134 months), and long-term survival (more than 5 years) was only documented in two cases without lymph node metastasis (including the present case). In conclusion, the experience gained in the present and previous cases suggests that long-term survival is possible following a curative resection in selected patients with ampullary SRCC without nodal involvement. Due to the lack of sufficient evidence, additional reports are warranted to determine whether SRCC also portends a poor prognosis in patients with ampullary cancer.

Original languageEnglish
Pages (from-to)1110-1114
Number of pages5
JournalSurgery Today
Volume37
Issue number12
DOIs
Publication statusPublished - 2007 Dec

Fingerprint

Signet Ring Cell Carcinoma
Ampulla of Vater
Biliary Tract Neoplasms
Neoplasms
Pancreaticoduodenectomy
Survival
Pruritus
Jaundice
Lymph Node Excision
Gastrointestinal Tract
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Recurrence

Keywords

  • Ampulla of Vater
  • Long-term survival
  • Signet-ring cell carcinoma

ASJC Scopus subject areas

  • Surgery

Cite this

Signet-ring cell carcinoma of the ampulla of Vater : Report of a case. / Akatsu, Tomotaka; Aiura, Koichi; Takahashi, Shin; Kameyama, Kaori; Kitajima, Masaki; Kitagawa, Yuukou.

In: Surgery Today, Vol. 37, No. 12, 12.2007, p. 1110-1114.

Research output: Contribution to journalArticle

Akatsu, Tomotaka ; Aiura, Koichi ; Takahashi, Shin ; Kameyama, Kaori ; Kitajima, Masaki ; Kitagawa, Yuukou. / Signet-ring cell carcinoma of the ampulla of Vater : Report of a case. In: Surgery Today. 2007 ; Vol. 37, No. 12. pp. 1110-1114.
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