TY - JOUR
T1 - Significance of biopsy with ERCP for diagnosis of bile duct invasion of DLBCL
AU - Ito, Yusuke
AU - Miyauchi, Masashi
AU - Nakamura, Tomoka
AU - Takahara, Naminatsu
AU - Nakai, Yousuke
AU - Taoka, Kazuki
AU - Toyama, Kazuhiro
AU - Shinozaki-Ushiku, Aya
AU - Koike, Kazuhiko
AU - Kurokawa, Mineo
N1 - Publisher Copyright:
© 2019, Japanese Society of Hematology.
PY - 2019/9/20
Y1 - 2019/9/20
N2 - Obstructive jaundice is an initial symptom in 1–2% of diffuse large B cell lymphoma (DLBCL) cases. The major cause of bile duct obstruction in patients with DLBCL is extrinsic compression by enlarged lymph nodes. In such cases, the existence of bile duct invasion of lymphoma is rarely mentioned or observed pathologically, so the ratio of bile duct invasion to the total cases of obstructive jaundice, and its significance remains unknown. We report two cases of DLBCL presenting as an obstructive jaundice, in which we demonstrated bile duct invasion pathologically by biopsy from the wall of common bile duct with endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic stent placement is a minimally invasive procedure to relieve cholestasis and is effective for diagnosing bile duct invasion. This procedure should thus be performed in all cases of obstructive jaundice caused by lymphoma to evaluate for bile duct invasion. Our cases suggest that ERCP may be useful as a diagnostic procedure for bile duct invasion.
AB - Obstructive jaundice is an initial symptom in 1–2% of diffuse large B cell lymphoma (DLBCL) cases. The major cause of bile duct obstruction in patients with DLBCL is extrinsic compression by enlarged lymph nodes. In such cases, the existence of bile duct invasion of lymphoma is rarely mentioned or observed pathologically, so the ratio of bile duct invasion to the total cases of obstructive jaundice, and its significance remains unknown. We report two cases of DLBCL presenting as an obstructive jaundice, in which we demonstrated bile duct invasion pathologically by biopsy from the wall of common bile duct with endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic stent placement is a minimally invasive procedure to relieve cholestasis and is effective for diagnosing bile duct invasion. This procedure should thus be performed in all cases of obstructive jaundice caused by lymphoma to evaluate for bile duct invasion. Our cases suggest that ERCP may be useful as a diagnostic procedure for bile duct invasion.
KW - Bile duct invasion
KW - Diffuse large B cell lymphoma (DLBCL)
KW - Endoscopic retrograde cholangiopancreatography (ERCP)
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U2 - 10.1007/s12185-019-02661-7
DO - 10.1007/s12185-019-02661-7
M3 - Article
C2 - 31093933
AN - SCOPUS:85066048381
SN - 0925-5710
VL - 110
SP - 381
EP - 384
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 3
ER -