TY - JOUR
T1 - Significance of CD66c expression in childhood acute lymphoblastic leukemia
AU - Kiyokawa, Nobutaka
AU - Iijima, Kazutoshi
AU - Tomita, Osamu
AU - Miharu, Masashi
AU - Hasegawa, Daisuke
AU - Kobayashi, Kenichiro
AU - Okita, Hajime
AU - Kajiwara, Michiko
AU - Shimada, Hiroyuki
AU - Inukai, Takeshi
AU - Makimoto, Atsushi
AU - Fukushima, Takashi
AU - Nanmoku, Toru
AU - Koh, Katsuyoshi
AU - Manabe, Atsushi
AU - Kikuchi, Akira
AU - Sugita, Kanji
AU - Fujimoto, Junichiro
AU - Hayashi, Yasuhide
AU - Ohara, Akira
N1 - Funding Information:
The authors thank the members of the ALL Committee of the TCCSG: Kazutoshi Koike, Hiroaki Goto, Takashi Kanazawa, Tetsuya Mori, Wataru Oyama, Junya Fujimura, Daisuke Toyama, Masa-aki Shiohara, Yasushi Noguchi, Setsuo Ohta, Hiromasa Yabe, Daisuke Tomizawa, Motohiro Kato, Hiroyuki Takahashi, Keitaro Fukushima, Takashi Kaneko, Takahiro Ueda, Ryosuke Kajiwara, Shinji Mochizuki, Manabu Sotomatsu, and Chitose Ogawa. We also thank Kaori Itagaki for preparing and refining the data of patients. This work was supported by a grant from Children's Cancer Association of Japan , Health and Labour Sciences Research Grants (the 3rd-term comprehensive 10-year strategy for cancer control H22-011), the Grant of National Center for Child Health and Development (25-2), a Grant-in-Aid for Young Scientists (B) ( 2479110 ), and the Advanced research for medical products Mining Programme of the National Institute of Biomedical Innovation (NIBIO, 10-41, -42, -43, -44, -45).
PY - 2014/1
Y1 - 2014/1
N2 - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.
AB - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.
KW - Acute lymphoblastic leukemia
KW - CD66c
KW - CRLF2, Flow cytometry
KW - Genetic abnormality
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U2 - 10.1016/j.leukres.2013.10.008
DO - 10.1016/j.leukres.2013.10.008
M3 - Article
AN - SCOPUS:84890547704
VL - 38
SP - 42
EP - 48
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 1
ER -
