Significance of CD66c expression in childhood acute lymphoblastic leukemia

Nobutaka Kiyokawa; Kazutoshi Iijima; Osamu Tomita; Masashi Miharu; Daisuke Hasegawa; Kenichiro Kobayashi; Hajime Okita; Michiko Kajiwara; Hiroyuki Shimada; Takeshi Inukai; Atsushi Makimoto; Takashi Fukushima; Toru Nanmoku; Katsuyoshi Koh; Atsushi Manabe; Akira Kikuchi; Kanji Sugita; Junichiro Fujimoto; Yasuhide Hayashi; Akira Ohara

doi:10.1016/j.leukres.2013.10.008

Significance of CD66c expression in childhood acute lymphoblastic leukemia

Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Takashi Fukushima, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Kanji Sugita, Junichiro Fujimoto, Yasuhide Hayashi, Akira Ohara

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

Original language	English
Pages (from-to)	42-48
Number of pages	7
Journal	Leukemia Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2013.10.008
Publication status	Published - 2014 Jan

Keywords

Acute lymphoblastic leukemia
CD66c
CRLF2, Flow cytometry
Genetic abnormality

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2013.10.008

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Kiyokawa, N., Iijima, K., Tomita, O., Miharu, M., Hasegawa, D., Kobayashi, K., Okita, H., Kajiwara, M., Shimada, H., Inukai, T., Makimoto, A., Fukushima, T., Nanmoku, T., Koh, K., Manabe, A., Kikuchi, A., Sugita, K., Fujimoto, J., Hayashi, Y., & Ohara, A. (2014). Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leukemia Research, 38(1), 42-48. https://doi.org/10.1016/j.leukres.2013.10.008

Significance of CD66c expression in childhood acute lymphoblastic leukemia. / Kiyokawa, Nobutaka; Iijima, Kazutoshi; Tomita, Osamu; Miharu, Masashi; Hasegawa, Daisuke; Kobayashi, Kenichiro; Okita, Hajime; Kajiwara, Michiko; Shimada, Hiroyuki; Inukai, Takeshi; Makimoto, Atsushi; Fukushima, Takashi; Nanmoku, Toru; Koh, Katsuyoshi; Manabe, Atsushi; Kikuchi, Akira; Sugita, Kanji; Fujimoto, Junichiro; Hayashi, Yasuhide; Ohara, Akira.

In: Leukemia Research, Vol. 38, No. 1, 01.2014, p. 42-48.

Research output: Contribution to journal › Article › peer-review

Kiyokawa, N, Iijima, K, Tomita, O, Miharu, M, Hasegawa, D, Kobayashi, K, Okita, H, Kajiwara, M, Shimada, H, Inukai, T, Makimoto, A, Fukushima, T, Nanmoku, T, Koh, K, Manabe, A, Kikuchi, A, Sugita, K, Fujimoto, J, Hayashi, Y & Ohara, A 2014, 'Significance of CD66c expression in childhood acute lymphoblastic leukemia', Leukemia Research, vol. 38, no. 1, pp. 42-48. https://doi.org/10.1016/j.leukres.2013.10.008

Kiyokawa, Nobutaka ; Iijima, Kazutoshi ; Tomita, Osamu ; Miharu, Masashi ; Hasegawa, Daisuke ; Kobayashi, Kenichiro ; Okita, Hajime ; Kajiwara, Michiko ; Shimada, Hiroyuki ; Inukai, Takeshi ; Makimoto, Atsushi ; Fukushima, Takashi ; Nanmoku, Toru ; Koh, Katsuyoshi ; Manabe, Atsushi ; Kikuchi, Akira ; Sugita, Kanji ; Fujimoto, Junichiro ; Hayashi, Yasuhide ; Ohara, Akira. / Significance of CD66c expression in childhood acute lymphoblastic leukemia. In: Leukemia Research. 2014 ; Vol. 38, No. 1. pp. 42-48.

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title = "Significance of CD66c expression in childhood acute lymphoblastic leukemia",

abstract = "Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.",

keywords = "Acute lymphoblastic leukemia, CD66c, CRLF2, Flow cytometry, Genetic abnormality",

author = "Nobutaka Kiyokawa and Kazutoshi Iijima and Osamu Tomita and Masashi Miharu and Daisuke Hasegawa and Kenichiro Kobayashi and Hajime Okita and Michiko Kajiwara and Hiroyuki Shimada and Takeshi Inukai and Atsushi Makimoto and Takashi Fukushima and Toru Nanmoku and Katsuyoshi Koh and Atsushi Manabe and Akira Kikuchi and Kanji Sugita and Junichiro Fujimoto and Yasuhide Hayashi and Akira Ohara",

note = "Funding Information: The authors thank the members of the ALL Committee of the TCCSG: Kazutoshi Koike, Hiroaki Goto, Takashi Kanazawa, Tetsuya Mori, Wataru Oyama, Junya Fujimura, Daisuke Toyama, Masa-aki Shiohara, Yasushi Noguchi, Setsuo Ohta, Hiromasa Yabe, Daisuke Tomizawa, Motohiro Kato, Hiroyuki Takahashi, Keitaro Fukushima, Takashi Kaneko, Takahiro Ueda, Ryosuke Kajiwara, Shinji Mochizuki, Manabu Sotomatsu, and Chitose Ogawa. We also thank Kaori Itagaki for preparing and refining the data of patients. This work was supported by a grant from Children's Cancer Association of Japan , Health and Labour Sciences Research Grants (the 3rd-term comprehensive 10-year strategy for cancer control H22-011), the Grant of National Center for Child Health and Development (25-2), a Grant-in-Aid for Young Scientists (B) ( 2479110 ), and the Advanced research for medical products Mining Programme of the National Institute of Biomedical Innovation (NIBIO, 10-41, -42, -43, -44, -45). ",

year = "2014",

month = jan,

doi = "10.1016/j.leukres.2013.10.008",

language = "English",

volume = "38",

pages = "42--48",

journal = "Leukemia Research",

issn = "0145-2126",

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T1 - Significance of CD66c expression in childhood acute lymphoblastic leukemia

AU - Kiyokawa, Nobutaka

AU - Iijima, Kazutoshi

AU - Tomita, Osamu

AU - Miharu, Masashi

AU - Hasegawa, Daisuke

AU - Kobayashi, Kenichiro

AU - Okita, Hajime

AU - Kajiwara, Michiko

AU - Shimada, Hiroyuki

AU - Inukai, Takeshi

AU - Makimoto, Atsushi

AU - Fukushima, Takashi

AU - Nanmoku, Toru

AU - Koh, Katsuyoshi

AU - Manabe, Atsushi

AU - Kikuchi, Akira

AU - Sugita, Kanji

AU - Fujimoto, Junichiro

AU - Hayashi, Yasuhide

AU - Ohara, Akira

N1 - Funding Information: The authors thank the members of the ALL Committee of the TCCSG: Kazutoshi Koike, Hiroaki Goto, Takashi Kanazawa, Tetsuya Mori, Wataru Oyama, Junya Fujimura, Daisuke Toyama, Masa-aki Shiohara, Yasushi Noguchi, Setsuo Ohta, Hiromasa Yabe, Daisuke Tomizawa, Motohiro Kato, Hiroyuki Takahashi, Keitaro Fukushima, Takashi Kaneko, Takahiro Ueda, Ryosuke Kajiwara, Shinji Mochizuki, Manabu Sotomatsu, and Chitose Ogawa. We also thank Kaori Itagaki for preparing and refining the data of patients. This work was supported by a grant from Children's Cancer Association of Japan , Health and Labour Sciences Research Grants (the 3rd-term comprehensive 10-year strategy for cancer control H22-011), the Grant of National Center for Child Health and Development (25-2), a Grant-in-Aid for Young Scientists (B) ( 2479110 ), and the Advanced research for medical products Mining Programme of the National Institute of Biomedical Innovation (NIBIO, 10-41, -42, -43, -44, -45).

PY - 2014/1

Y1 - 2014/1

N2 - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

AB - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

KW - Acute lymphoblastic leukemia

KW - CD66c

KW - CRLF2, Flow cytometry

KW - Genetic abnormality

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SP - 42

EP - 48

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

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ER -

Significance of CD66c expression in childhood acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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