Significance of CD66c expression in childhood acute lymphoblastic leukemia

Nobutaka Kiyokawa; Kazutoshi Iijima; Osamu Tomita; Masashi Miharu; Daisuke Hasegawa; Kenichiro Kobayashi; Hajime Okita; Michiko Kajiwara; Hiroyuki Shimada; Takeshi Inukai; Atsushi Makimoto; Takashi Fukushima; Toru Nanmoku; Katsuyoshi Koh; Atsushi Manabe; Akira Kikuchi; Kanji Sugita; Junichiro Fujimoto; Yasuhide Hayashi; Akira Ohara

doi:10.1016/j.leukres.2013.10.008

Significance of CD66c expression in childhood acute lymphoblastic leukemia

Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Takashi Fukushima, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Kanji Sugita, Junichiro Fujimoto, Yasuhide Hayashi, Akira Ohara

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

Original language	English
Pages (from-to)	42-48
Number of pages	7
Journal	Leukemia Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2013.10.008
Publication status	Published - 2014 Jan

Keywords

Acute lymphoblastic leukemia
CD66c
CRLF2, Flow cytometry
Genetic abnormality

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Kiyokawa, N., Iijima, K., Tomita, O., Miharu, M., Hasegawa, D., Kobayashi, K., Okita, H., Kajiwara, M., Shimada, H., Inukai, T., Makimoto, A., Fukushima, T., Nanmoku, T., Koh, K., Manabe, A., Kikuchi, A., Sugita, K., Fujimoto, J., Hayashi, Y., & Ohara, A. (2014). Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leukemia Research, 38(1), 42-48. https://doi.org/10.1016/j.leukres.2013.10.008

Significance of CD66c expression in childhood acute lymphoblastic leukemia. / Kiyokawa, Nobutaka; Iijima, Kazutoshi; Tomita, Osamu; Miharu, Masashi; Hasegawa, Daisuke; Kobayashi, Kenichiro; Okita, Hajime; Kajiwara, Michiko; Shimada, Hiroyuki; Inukai, Takeshi; Makimoto, Atsushi; Fukushima, Takashi; Nanmoku, Toru; Koh, Katsuyoshi; Manabe, Atsushi; Kikuchi, Akira; Sugita, Kanji; Fujimoto, Junichiro; Hayashi, Yasuhide; Ohara, Akira.

In: Leukemia Research, Vol. 38, No. 1, 01.2014, p. 42-48.

Research output: Contribution to journal › Article

Kiyokawa, N, Iijima, K, Tomita, O, Miharu, M, Hasegawa, D, Kobayashi, K, Okita, H, Kajiwara, M, Shimada, H, Inukai, T, Makimoto, A, Fukushima, T, Nanmoku, T, Koh, K, Manabe, A, Kikuchi, A, Sugita, K, Fujimoto, J, Hayashi, Y & Ohara, A 2014, 'Significance of CD66c expression in childhood acute lymphoblastic leukemia', Leukemia Research, vol. 38, no. 1, pp. 42-48. https://doi.org/10.1016/j.leukres.2013.10.008

Kiyokawa, Nobutaka ; Iijima, Kazutoshi ; Tomita, Osamu ; Miharu, Masashi ; Hasegawa, Daisuke ; Kobayashi, Kenichiro ; Okita, Hajime ; Kajiwara, Michiko ; Shimada, Hiroyuki ; Inukai, Takeshi ; Makimoto, Atsushi ; Fukushima, Takashi ; Nanmoku, Toru ; Koh, Katsuyoshi ; Manabe, Atsushi ; Kikuchi, Akira ; Sugita, Kanji ; Fujimoto, Junichiro ; Hayashi, Yasuhide ; Ohara, Akira. / Significance of CD66c expression in childhood acute lymphoblastic leukemia. In: Leukemia Research. 2014 ; Vol. 38, No. 1. pp. 42-48.

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abstract = "Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.",

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AU - Kobayashi, Kenichiro

AU - Okita, Hajime

AU - Kajiwara, Michiko

AU - Shimada, Hiroyuki

AU - Inukai, Takeshi

AU - Makimoto, Atsushi

AU - Fukushima, Takashi

AU - Nanmoku, Toru

AU - Koh, Katsuyoshi

AU - Manabe, Atsushi

AU - Kikuchi, Akira

AU - Sugita, Kanji

AU - Fujimoto, Junichiro

AU - Hayashi, Yasuhide

AU - Ohara, Akira

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N2 - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

AB - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

KW - Acute lymphoblastic leukemia

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KW - CRLF2, Flow cytometry

KW - Genetic abnormality

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