Abstract
Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.
| Original language | English |
|---|---|
| Pages (from-to) | 42-48 |
| Number of pages | 7 |
| Journal | Leukemia Research |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan |
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Keywords
- Acute lymphoblastic leukemia
- CD66c
- CRLF2, Flow cytometry
- Genetic abnormality
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Significance of CD66c expression in childhood acute lymphoblastic leukemia. / Kiyokawa, Nobutaka; Iijima, Kazutoshi; Tomita, Osamu; Miharu, Masashi; Hasegawa, Daisuke; Kobayashi, Kenichiro; Okita, Hajime; Kajiwara, Michiko; Shimada, Hiroyuki; Inukai, Takeshi; Makimoto, Atsushi; Fukushima, Takashi; Nanmoku, Toru; Koh, Katsuyoshi; Manabe, Atsushi; Kikuchi, Akira; Sugita, Kanji; Fujimoto, Junichiro; Hayashi, Yasuhide; Ohara, Akira.
In: Leukemia Research, Vol. 38, No. 1, 01.2014, p. 42-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significance of CD66c expression in childhood acute lymphoblastic leukemia
AU - Kiyokawa, Nobutaka
AU - Iijima, Kazutoshi
AU - Tomita, Osamu
AU - Miharu, Masashi
AU - Hasegawa, Daisuke
AU - Kobayashi, Kenichiro
AU - Okita, Hajime
AU - Kajiwara, Michiko
AU - Shimada, Hiroyuki
AU - Inukai, Takeshi
AU - Makimoto, Atsushi
AU - Fukushima, Takashi
AU - Nanmoku, Toru
AU - Koh, Katsuyoshi
AU - Manabe, Atsushi
AU - Kikuchi, Akira
AU - Sugita, Kanji
AU - Fujimoto, Junichiro
AU - Hayashi, Yasuhide
AU - Ohara, Akira
PY - 2014/1
Y1 - 2014/1
N2 - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.
AB - Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.
KW - Acute lymphoblastic leukemia
KW - CD66c
KW - CRLF2, Flow cytometry
KW - Genetic abnormality
UR - http://www.scopus.com/inward/record.url?scp=84890547704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890547704&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2013.10.008
DO - 10.1016/j.leukres.2013.10.008
M3 - Article
AN - SCOPUS:84890547704
VL - 38
SP - 42
EP - 48
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 1
ER -