Significance of CD66c expression in childhood acute lymphoblastic leukemia

Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Takashi Fukushima, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Kanji Sugita, Junichiro Fujimoto, Yasuhide Hayashi, Akira Ohara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalLeukemia Research
Volume38
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • Acute lymphoblastic leukemia
  • CD66c
  • CRLF2, Flow cytometry
  • Genetic abnormality

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Kiyokawa, N., Iijima, K., Tomita, O., Miharu, M., Hasegawa, D., Kobayashi, K., Okita, H., Kajiwara, M., Shimada, H., Inukai, T., Makimoto, A., Fukushima, T., Nanmoku, T., Koh, K., Manabe, A., Kikuchi, A., Sugita, K., Fujimoto, J., Hayashi, Y., & Ohara, A. (2014). Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leukemia Research, 38(1), 42-48. https://doi.org/10.1016/j.leukres.2013.10.008