Significance of echocardiographic assessment for right ventricular function after balloon pulmonary angioplasty in patients with chronic thromboembolic induced pulmonary hypertension

Toshimitsu Tsugu, Mitsushige Murata, Takashi Kawakami, Risako Yasuda, Hanako Tokuda, Yugo Minakata, Yuichi Tamura, Masaharu Kataoka, Kentaro Hayashida, Hikaru Tsuruta, Yuichiro Maekawa, Soushin Inoue, Keiichi Fukuda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Balloon pulmonary angioplasty (BPA) may improve hemodynamics and exercise tolerance in patients with chronic thromboembolic pulmonary hypertension (CTEPH). We studied consecutive 25 patients with CTEPH who underwent BPA and evaluated hemodynamics by right-sided heart catheterization. Right ventricular (RV) function was assessed before and after BPA by echocardiography including speckle-tracking echocardiography and 3-dimensional echocardiography. BPA improved the mean pulmonary artery pressure, pulmonary vascular resistance, and cardiac index. BPA also ameliorated the 3-dimentional RV volume, RV ejection fraction, and RV systolic peak strain, all of which were significantly correlated with hemodynamic parameters. The changes in cardiac index were significantly correlated with those in 3-dimentional RV volume index. Furthermore, RV dyssynchrony quantified by the RV strain analyses was ameliorated after BPA even in patients with mild pulmonary hypertension, implicating the merit of BPA in this patient population with CTEPH. BPA not only improved the hemodynamics in patients with CTEPH, but also ameliorated RV remodeling and dyssynchrony as assessed by 3-dimensional echocardiography or speckle-tracking echocardiography. Thus, the assessment of RV function may provide valuable information about the appropriate indication for BPA, its efficacy, and the therapeutic goal for patients with CTEPH.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalAmerican Journal of Cardiology
Volume115
Issue number2
DOIs
Publication statusPublished - 2015 Jan 15

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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