Significance of ini-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma

Yuukou Kitagawa, Masakazu Ueda, Nobutoshi Ando, Yohtaro Shinozawa, Nobuyoshi Shimizu, Osahiko Abe

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Abstract

The correlation between the clinical outcome in patients with esophageal squamous cell carcinoma and coamplification of the proto-oncogenes int-2 and hst-1, which are partially homologous to angiogenesis-inducing fibroblast growth factor, was analyzed retrospectively. Coamplification of these genes was examined by slot-blot hybridization using DNAs extracted from formalin-fixed and paraffin-embedded blocks of tissues. These tissues were obtained from 107 patients with esophageal squamous cell carcinoma who had undergone radical surgery. Int-2/hst-1 coamplification greater than 3-fold was observed in the primary tumors of 30 of 107 cases (28%), and in the metastatic lymph nodes of 12 of 40 cases (30%). The cumulative survival rate of patients with int-2/hst-1 coamplification in the primary tumors was significantly lower than that of the patients without coamplification (P < 0.001), and there were no significant differences between the clinicopathological backgrounds of the 2 groups. Int-2/hst-1 coamplification was also significantly correlated with a high incidence of eventual metastasis in distant organs in these patients. These results suggest that int-2/hst-1 coamplification is a new biological indicator of prognosis and distant organ metastasis in patients with esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1504-1508
Number of pages5
JournalCancer Research
Volume51
Issue number5
Publication statusPublished - 1991 Mar 1

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Squamous Cell Carcinoma
Neoplasm Metastasis
Proto-Oncogenes
Fibroblast Growth Factors
Paraffin
Formaldehyde
Neoplasms
Survival Rate
Lymph Nodes
DNA
Incidence
Genes
Esophageal Squamous Cell Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Significance of ini-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. / Kitagawa, Yuukou; Ueda, Masakazu; Ando, Nobutoshi; Shinozawa, Yohtaro; Shimizu, Nobuyoshi; Abe, Osahiko.

In: Cancer Research, Vol. 51, No. 5, 01.03.1991, p. 1504-1508.

Research output: Contribution to journalArticle

Kitagawa, Y, Ueda, M, Ando, N, Shinozawa, Y, Shimizu, N & Abe, O 1991, 'Significance of ini-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma', Cancer Research, vol. 51, no. 5, pp. 1504-1508.
Kitagawa, Yuukou ; Ueda, Masakazu ; Ando, Nobutoshi ; Shinozawa, Yohtaro ; Shimizu, Nobuyoshi ; Abe, Osahiko. / Significance of ini-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. In: Cancer Research. 1991 ; Vol. 51, No. 5. pp. 1504-1508.
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