Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents

Hiroshi Nakatani, Hiroshi Hirose, Yukihiro Yamamoto, Ikuo Saito, Hiroshi Itoh

Research output: Contribution to journalArticle

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Abstract

Adipokines play crucial roles in obesity-related insulin resistance in adults, but little is known in the general adolescent population. This study was designed to investigate the relationships between adipokines and metabolic parameters, the insulin resistance index, and proinflammatory cytokines in the general population of Japanese male adolescents. We studied 662 Japanese male high school students aged 16 to 17 years and 282 healthy Japanese male adults aged 30 to 61 years who received annual health checkups. High-molecular weight (HMW) adiponectin levels were significantly lower in adolescents (4.18 ± 2.24 μg/mL) than in adults (4.84 ± 3.20 μg/mL), despite body mass index (BMI) being significantly lower in adolescents. The HMW adiponectin levels correlated negatively with BMI and the homeostasis model assessment of insulin resistance index (HOMA-IR) in adults. In adolescents, HMW adiponectin correlated negatively with BMI and waist circumference, but not with HOMA-IR or other metabolic parameters except high-density lipoprotein cholesterol. Leptin levels correlated positively with HOMA-IR, triglycerides, tumor necrosis factor α, interleukin 6, and monocyte chemoattractant protein 1 and negatively with high-density lipoprotein cholesterol even after adjustment for BMI. These findings suggest that serum leptin is a more useful biomarker of fat accumulation-related insulin resistance, inflammation, and metabolic abnormalities than HMW adiponectin in the general population of male adolescents. The inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume57
Issue number2
DOIs
Publication statusPublished - 2008 Feb

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Adiponectin
Leptin
Insulin Resistance
Molecular Weight
Body Mass Index
Population
Adipokines
Homeostasis
HDL Cholesterol
Obesity
Chemokine CCL2
Waist Circumference
Interleukin-6
Triglycerides
Tumor Necrosis Factor-alpha
Biomarkers
Fats
Cytokines
Students
Inflammation

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents. / Nakatani, Hiroshi; Hirose, Hiroshi; Yamamoto, Yukihiro; Saito, Ikuo; Itoh, Hiroshi.

In: Metabolism: Clinical and Experimental, Vol. 57, No. 2, 02.2008, p. 157-162.

Research output: Contribution to journalArticle

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