Significance of renin-angiotensin system in diabetes mellitus with hypertension

Research output: Contribution to journalReview article

Abstract

Diabetes mellitus and hypertension frequently occur in the same individual, based upon 'insulin resistance', which is caused by obesity and impairment of secretion of several adipocyte-derived hormones(adipocytokines), including leptin and adiponectin. Insulin resistance and activation of tissue renin-angiotensin system mutually affect each other to promote diabetes mellitus/hypertension and their complications. Especially, renin-angiotensin system in the adipose tissue modulate adipocyte differentiation and adipose tissue mass. Vascular renin-angiotensin system causes endothelial dysfunction and promotes inflammatory process to accelerate atherosclerosis. Blockade of renin-angiotensin system is reasonable for prevention and suppression of diabetes mellitus/hypertension and their complications.

Original languageEnglish
Pages (from-to)1145-1153
Number of pages9
JournalNippon rinsho. Japanese journal of clinical medicine
Volume61
Issue number7
Publication statusPublished - 2003 Jul
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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