Abstract
Diabetes mellitus and hypertension frequently occur in the same individual, based upon 'insulin resistance', which is caused by obesity and impairment of secretion of several adipocyte-derived hormones(adipocytokines), including leptin and adiponectin. Insulin resistance and activation of tissue renin-angiotensin system mutually affect each other to promote diabetes mellitus/hypertension and their complications. Especially, renin-angiotensin system in the adipose tissue modulate adipocyte differentiation and adipose tissue mass. Vascular renin-angiotensin system causes endothelial dysfunction and promotes inflammatory process to accelerate atherosclerosis. Blockade of renin-angiotensin system is reasonable for prevention and suppression of diabetes mellitus/hypertension and their complications.
| Original language | English |
|---|---|
| Pages (from-to) | 1145-1153 |
| Number of pages | 9 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 61 |
| Issue number | 7 |
| Publication status | Published - 2003 Jul |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
