Significance of serum antibody against surface antigens of Actinobacillus actinomycetemcomitans in patients with adult periodontitis.

A. Saito, Y. Hosaka, Taneaki Nakagawa, K. Seida, S. Yamada, I. Takazoe, K. Okuda

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This study was undertaken to examine the prevalence of Actinobacillus actinomycetemcomitans, its serotype distribution and the serum immune responses against its surface antigens in 41 Japanese patients with adult periodontitis. The dominant A. actinomycetemcomitans serotype isolated was serotype c. Immunoblot analysis of 3 serotypes of A. actinomycetemcomitans-sonicated antigens and the patient sera revealed that the reactivities with serotype c were the most frequent and that heat-stable surface serotype-specific antigen appeared to be immunodominant. Elevated serum immunoglobulin G titers to extracted lipopolysaccharide and fimbriae antigen of A. actinomycetemcomitans were noted for the patient sera by enzyme-linked immunosorbent assay. High serum immunoglobulin G titers to the fimbriae antigen detected in patients without cultivable A. actinomycetemcomitans suggested the possibility that the elicited antibody to the antigen played a role in eliminating A. actinomycetemcomitans from the periodontal lesions.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalOral Microbiology and Immunology
Volume8
Issue number3
Publication statusPublished - 1993 Jun
Externally publishedYes

Fingerprint

Aggregatibacter actinomycetemcomitans
Chronic Periodontitis
Surface Antigens
Antibodies
Antigens
Serum
Immunoglobulin G
Lipopolysaccharides
Serogroup
Immune Sera
Hot Temperature
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Dentistry(all)

Cite this

Significance of serum antibody against surface antigens of Actinobacillus actinomycetemcomitans in patients with adult periodontitis. / Saito, A.; Hosaka, Y.; Nakagawa, Taneaki; Seida, K.; Yamada, S.; Takazoe, I.; Okuda, K.

In: Oral Microbiology and Immunology, Vol. 8, No. 3, 06.1993, p. 146-153.

Research output: Contribution to journalArticle

@article{e6c14b2688a7436bb438c467345d7c62,
title = "Significance of serum antibody against surface antigens of Actinobacillus actinomycetemcomitans in patients with adult periodontitis.",
abstract = "This study was undertaken to examine the prevalence of Actinobacillus actinomycetemcomitans, its serotype distribution and the serum immune responses against its surface antigens in 41 Japanese patients with adult periodontitis. The dominant A. actinomycetemcomitans serotype isolated was serotype c. Immunoblot analysis of 3 serotypes of A. actinomycetemcomitans-sonicated antigens and the patient sera revealed that the reactivities with serotype c were the most frequent and that heat-stable surface serotype-specific antigen appeared to be immunodominant. Elevated serum immunoglobulin G titers to extracted lipopolysaccharide and fimbriae antigen of A. actinomycetemcomitans were noted for the patient sera by enzyme-linked immunosorbent assay. High serum immunoglobulin G titers to the fimbriae antigen detected in patients without cultivable A. actinomycetemcomitans suggested the possibility that the elicited antibody to the antigen played a role in eliminating A. actinomycetemcomitans from the periodontal lesions.",
author = "A. Saito and Y. Hosaka and Taneaki Nakagawa and K. Seida and S. Yamada and I. Takazoe and K. Okuda",
year = "1993",
month = "6",
language = "English",
volume = "8",
pages = "146--153",
journal = "Molecular Oral Microbiology",
issn = "2041-1006",
publisher = "American Journal of Nursing Company",
number = "3",

}

TY - JOUR

T1 - Significance of serum antibody against surface antigens of Actinobacillus actinomycetemcomitans in patients with adult periodontitis.

AU - Saito, A.

AU - Hosaka, Y.

AU - Nakagawa, Taneaki

AU - Seida, K.

AU - Yamada, S.

AU - Takazoe, I.

AU - Okuda, K.

PY - 1993/6

Y1 - 1993/6

N2 - This study was undertaken to examine the prevalence of Actinobacillus actinomycetemcomitans, its serotype distribution and the serum immune responses against its surface antigens in 41 Japanese patients with adult periodontitis. The dominant A. actinomycetemcomitans serotype isolated was serotype c. Immunoblot analysis of 3 serotypes of A. actinomycetemcomitans-sonicated antigens and the patient sera revealed that the reactivities with serotype c were the most frequent and that heat-stable surface serotype-specific antigen appeared to be immunodominant. Elevated serum immunoglobulin G titers to extracted lipopolysaccharide and fimbriae antigen of A. actinomycetemcomitans were noted for the patient sera by enzyme-linked immunosorbent assay. High serum immunoglobulin G titers to the fimbriae antigen detected in patients without cultivable A. actinomycetemcomitans suggested the possibility that the elicited antibody to the antigen played a role in eliminating A. actinomycetemcomitans from the periodontal lesions.

AB - This study was undertaken to examine the prevalence of Actinobacillus actinomycetemcomitans, its serotype distribution and the serum immune responses against its surface antigens in 41 Japanese patients with adult periodontitis. The dominant A. actinomycetemcomitans serotype isolated was serotype c. Immunoblot analysis of 3 serotypes of A. actinomycetemcomitans-sonicated antigens and the patient sera revealed that the reactivities with serotype c were the most frequent and that heat-stable surface serotype-specific antigen appeared to be immunodominant. Elevated serum immunoglobulin G titers to extracted lipopolysaccharide and fimbriae antigen of A. actinomycetemcomitans were noted for the patient sera by enzyme-linked immunosorbent assay. High serum immunoglobulin G titers to the fimbriae antigen detected in patients without cultivable A. actinomycetemcomitans suggested the possibility that the elicited antibody to the antigen played a role in eliminating A. actinomycetemcomitans from the periodontal lesions.

UR - http://www.scopus.com/inward/record.url?scp=0027620088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027620088&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 146

EP - 153

JO - Molecular Oral Microbiology

JF - Molecular Oral Microbiology

SN - 2041-1006

IS - 3

ER -