Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (γ-GTP) activity in non-drinkers

Hirokazu Yokoyama, Hiroshi Hirose, Susumu Moriya, Ikuo Saito

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To understand the significance of elevated serum γ-GTP levels, factors relevant to the serum γ-GTP level were studied using data of health check-ups for the employees of a Japanese corporation. The γ-GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the γ-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the γ-GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non-drinkers and opportunity drinkers were selectively studied, 63.6% of subjects whose γ-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum γ-GTP activity in clinical subjects.

Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume26
Issue number8 SUPPL.
Publication statusPublished - 2002 Aug

Fingerprint

gamma-Glutamyltransferase
Guanosine Triphosphate
Insulin Resistance
Insulin
Serum
Liver Function Tests
Aspartate Aminotransferases
Uric Acid
Alanine Transaminase
Liver
LDL Cholesterol
Triglycerides
Body Mass Index
Cholesterol
Health
Personnel
Industry

Keywords

  • γ-GTP
  • Drinking Style
  • Insulin Resistance

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

@article{81c9e522d223469d85bed4d8a302af18,
title = "Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (γ-GTP) activity in non-drinkers",
abstract = "To understand the significance of elevated serum γ-GTP levels, factors relevant to the serum γ-GTP level were studied using data of health check-ups for the employees of a Japanese corporation. The γ-GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the γ-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the γ-GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non-drinkers and opportunity drinkers were selectively studied, 63.6{\%} of subjects whose γ-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum γ-GTP activity in clinical subjects.",
keywords = "γ-GTP, Drinking Style, Insulin Resistance",
author = "Hirokazu Yokoyama and Hiroshi Hirose and Susumu Moriya and Ikuo Saito",
year = "2002",
month = "8",
language = "English",
volume = "26",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "8 SUPPL.",

}

TY - JOUR

T1 - Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (γ-GTP) activity in non-drinkers

AU - Yokoyama, Hirokazu

AU - Hirose, Hiroshi

AU - Moriya, Susumu

AU - Saito, Ikuo

PY - 2002/8

Y1 - 2002/8

N2 - To understand the significance of elevated serum γ-GTP levels, factors relevant to the serum γ-GTP level were studied using data of health check-ups for the employees of a Japanese corporation. The γ-GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the γ-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the γ-GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non-drinkers and opportunity drinkers were selectively studied, 63.6% of subjects whose γ-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum γ-GTP activity in clinical subjects.

AB - To understand the significance of elevated serum γ-GTP levels, factors relevant to the serum γ-GTP level were studied using data of health check-ups for the employees of a Japanese corporation. The γ-GTP level was positively correlated with levels of various liver function tests including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Except for them, the γ-GTP level was positively correlated with levels of insulin resistance, uric acid, total cholesterol, triglyceride, and body mass index. The correlation between the γ-GTP level and LDL cholesterol was also observed only when subjects who drank more than 5 times a week were selectively studied. When non-drinkers and opportunity drinkers were selectively studied, 63.6% of subjects whose γ-GTP level was more than 120 IU/liter showed elevated insulin resistance levels. Multiple factors including insulin resistance may affect serum γ-GTP activity in clinical subjects.

KW - γ-GTP

KW - Drinking Style

KW - Insulin Resistance

UR - http://www.scopus.com/inward/record.url?scp=0036667824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036667824&partnerID=8YFLogxK

M3 - Article

C2 - 12198383

AN - SCOPUS:0036667824

VL - 26

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 8 SUPPL.

ER -