Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells

Asako Kurauchi-Mito, Atsuhiro Ichihara, Kanako Bokuda, Mariyo Sakoda, Kenichiro Kinouchi, Tomonori Yaguchi, Taketo Yamada, Ge Hong Sun-Wada, Yoh Wada, Hiroshi Itoh

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15 Citations (Scopus)

Abstract

The (pro)renin receptor ((P)RR) is known to play an important role in the pathogenesis of vascular complications in diabetes mellitus and hypertension through its function in activating the local renin-Angiotensin system. Recent studies have shown that the (P)RR is an accessory protein of the vacuolar H + -ATPase, suggesting a more fundamental and developmental function. In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H + -ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H + -ATPase. copy; 2014 The Japanese Society of Hypertension All rights reserved.

Original languageEnglish
Pages (from-to)830-835
Number of pages6
JournalHypertension Research
Volume37
Issue number9
DOIs
Publication statusPublished - 2014 Sep 11

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Kurauchi-Mito, A., Ichihara, A., Bokuda, K., Sakoda, M., Kinouchi, K., Yaguchi, T., Yamada, T., Sun-Wada, G. H., Wada, Y., & Itoh, H. (2014). Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells. Hypertension Research, 37(9), 830-835. https://doi.org/10.1038/hr.2014.92