Sildenafil reduces pulmonary vascular resistance in single ventricular physiology

Hiroki Mori; In Sam Park; Hiroyuki Yamagishi; Makoto Nakamura; Shiro Ishikawa; Kiyohiro Takigiku; Satoshi Yasukochi; Tomotaka Nakayama; Tsutomu Saji; Toshio Nakanishi

doi:10.1016/j.ijcard.2016.06.322

Sildenafil reduces pulmonary vascular resistance in single ventricular physiology

Hiroki Mori, In Sam Park, Hiroyuki Yamagishi, Makoto Nakamura, Shiro Ishikawa, Kiyohiro Takigiku, Satoshi Yasukochi, Tomotaka Nakayama, Tsutomu Saji, Toshio Nakanishi

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

Background High pulmonary vascular resistance (PVR) may be a risk factor for early and late mortality in both Glen shunt and Fontan operation patients. Furthermore, PVR may increase long after the Fontan operation. Whether pulmonary vasodilators such as phosphodiesterase 5 inhibitors can decrease PVR in patients with single ventricular physiology remains undetermined. Methods and results This was a prospective, multicenter study. Patients with single ventricular physiology who have a PVR index higher than 2.5 Wood units·㎡ (WU) were enrolled. Cardiac catheterization was performed before and after administration of sildenafil in all patients. After the Fontan operation, a six minute walk test (6 MWT) was also performed. A total of 42 patients were enrolled. PVR was significantly decreased in each stage of single ventricular physiology after sildenafil administration: from 4.3 ± 1.5 WU to 2.1 ± 0.6 WU (p

Original language	English
Pages (from-to)	122-127
Number of pages	6
Journal	International Journal of Cardiology
Volume	221
DOIs	https://doi.org/10.1016/j.ijcard.2016.06.322
Publication status	Published - 2016 Oct 15
Externally published	Yes

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ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Cite this

Mori, H., Park, I. S., Yamagishi, H., Nakamura, M., Ishikawa, S., Takigiku, K., Yasukochi, S., Nakayama, T., Saji, T., & Nakanishi, T. (2016). Sildenafil reduces pulmonary vascular resistance in single ventricular physiology. International Journal of Cardiology, 221, 122-127. https://doi.org/10.1016/j.ijcard.2016.06.322

Sildenafil reduces pulmonary vascular resistance in single ventricular physiology. / Mori, Hiroki; Park, In Sam; Yamagishi, Hiroyuki; Nakamura, Makoto; Ishikawa, Shiro; Takigiku, Kiyohiro; Yasukochi, Satoshi; Nakayama, Tomotaka; Saji, Tsutomu; Nakanishi, Toshio.

In: International Journal of Cardiology, Vol. 221, 15.10.2016, p. 122-127.

Research output: Contribution to journal › Article

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abstract = "Background High pulmonary vascular resistance (PVR) may be a risk factor for early and late mortality in both Glen shunt and Fontan operation patients. Furthermore, PVR may increase long after the Fontan operation. Whether pulmonary vasodilators such as phosphodiesterase 5 inhibitors can decrease PVR in patients with single ventricular physiology remains undetermined. Methods and results This was a prospective, multicenter study. Patients with single ventricular physiology who have a PVR index higher than 2.5 Wood units·㎡ (WU) were enrolled. Cardiac catheterization was performed before and after administration of sildenafil in all patients. After the Fontan operation, a six minute walk test (6 MWT) was also performed. A total of 42 patients were enrolled. PVR was significantly decreased in each stage of single ventricular physiology after sildenafil administration: from 4.3 ± 1.5 WU to 2.1 ± 0.6 WU (p ",

author = "Hiroki Mori and Park, {In Sam} and Hiroyuki Yamagishi and Makoto Nakamura and Shiro Ishikawa and Kiyohiro Takigiku and Satoshi Yasukochi and Tomotaka Nakayama and Tsutomu Saji and Toshio Nakanishi",

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AU - Mori, Hiroki

AU - Park, In Sam

AU - Yamagishi, Hiroyuki

AU - Nakamura, Makoto

AU - Ishikawa, Shiro

AU - Takigiku, Kiyohiro

AU - Yasukochi, Satoshi

AU - Nakayama, Tomotaka

AU - Saji, Tsutomu

AU - Nakanishi, Toshio

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N2 - Background High pulmonary vascular resistance (PVR) may be a risk factor for early and late mortality in both Glen shunt and Fontan operation patients. Furthermore, PVR may increase long after the Fontan operation. Whether pulmonary vasodilators such as phosphodiesterase 5 inhibitors can decrease PVR in patients with single ventricular physiology remains undetermined. Methods and results This was a prospective, multicenter study. Patients with single ventricular physiology who have a PVR index higher than 2.5 Wood units·㎡ (WU) were enrolled. Cardiac catheterization was performed before and after administration of sildenafil in all patients. After the Fontan operation, a six minute walk test (6 MWT) was also performed. A total of 42 patients were enrolled. PVR was significantly decreased in each stage of single ventricular physiology after sildenafil administration: from 4.3 ± 1.5 WU to 2.1 ± 0.6 WU (p

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10.1016/j.ijcard.2016.06.322