TY - JOUR
T1 - Sildenafil reduces pulmonary vascular resistance in single ventricular physiology
AU - Mori, Hiroki
AU - Park, In Sam
AU - Yamagishi, Hiroyuki
AU - Nakamura, Makoto
AU - Ishikawa, Shiro
AU - Takigiku, Kiyohiro
AU - Yasukochi, Satoshi
AU - Nakayama, Tomotaka
AU - Saji, Tsutomu
AU - Nakanishi, Toshio
PY - 2016/10/15
Y1 - 2016/10/15
N2 - Background High pulmonary vascular resistance (PVR) may be a risk factor for early and late mortality in both Glen shunt and Fontan operation patients. Furthermore, PVR may increase long after the Fontan operation. Whether pulmonary vasodilators such as phosphodiesterase 5 inhibitors can decrease PVR in patients with single ventricular physiology remains undetermined. Methods and results This was a prospective, multicenter study. Patients with single ventricular physiology who have a PVR index higher than 2.5 Wood units·㎡ (WU) were enrolled. Cardiac catheterization was performed before and after administration of sildenafil in all patients. After the Fontan operation, a six minute walk test (6 MWT) was also performed. A total of 42 patients were enrolled. PVR was significantly decreased in each stage of single ventricular physiology after sildenafil administration: from 4.3 ± 1.5 WU to 2.1 ± 0.6 WU (p
AB - Background High pulmonary vascular resistance (PVR) may be a risk factor for early and late mortality in both Glen shunt and Fontan operation patients. Furthermore, PVR may increase long after the Fontan operation. Whether pulmonary vasodilators such as phosphodiesterase 5 inhibitors can decrease PVR in patients with single ventricular physiology remains undetermined. Methods and results This was a prospective, multicenter study. Patients with single ventricular physiology who have a PVR index higher than 2.5 Wood units·㎡ (WU) were enrolled. Cardiac catheterization was performed before and after administration of sildenafil in all patients. After the Fontan operation, a six minute walk test (6 MWT) was also performed. A total of 42 patients were enrolled. PVR was significantly decreased in each stage of single ventricular physiology after sildenafil administration: from 4.3 ± 1.5 WU to 2.1 ± 0.6 WU (p
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U2 - 10.1016/j.ijcard.2016.06.322
DO - 10.1016/j.ijcard.2016.06.322
M3 - Article
C2 - 27400308
AN - SCOPUS:84978131614
VL - 221
SP - 122
EP - 127
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -