Silver-Catalyzed Carbon Dioxide Fixation on Alkynylindoles

Seiya Uema, Kodai Saito, Tohru Yamada

Research output: Contribution to journalArticlepeer-review

Abstract

A silver-catalyzed carbon dioxide fixation reaction into 2-alkynylindole derivatives was developed to afford tricyclic indoles. Carbon dioxide was selectively fixed on the N atom of the indole, and only 6-endo-dig cyclization proceeded under mild reaction conditions. Carboxylation on C3 of the indole was not observed. This method was applicable for a variety of 2-alkynylindoles, and the corresponding products were obtained in high yields without the production of side products.

Original languageEnglish
Pages (from-to)4831-4834
Number of pages4
JournalOrganic Letters
Volume24
Issue number26
DOIs
Publication statusPublished - 2022 Jul 8

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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