Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells

Ukei Anazawa, Hideya Hanaoka, Tateru Shiraishi, Hideo Morioka, Takeshi Morii, Yoshiaki Toyama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The authors investigated ultrastructural cytochemical features of multinucleated and mononuclear stromal cells in giant cell tumor of bone (GCTB), giant cell tumor of tendon sheath (GCTTS), and pigmented villonodular synovitis (PVNS). Specimens of each tumor, respectively numbering 4, 4, and 3, were stained for tartrate-resistant acid phosphatase (TRAP) reactions and examined with an electron microscope. In GCTB and GCTTS, multinucleated cells, including some relatively small giant cells, showed TRAP activity and cytoplasmic features characteristic of osteoclasts, and also sometimes abundant rough endoplasmic reticulum and siderosomes. A few giant cells with macrophage-like features and slight TRAP activity were demonstrated in GCCTS and PVNS. In each tumor type, mononuclear cells showing TRAP activity shared cytoplasmic features with osteoclast-like multinucleated giant cells, while some others had macrophage-like features, and still others were poorly differentiated; a few mononuclear cells showed cell-to-cell contact. Ultrastructural similarities of TRAP-positive mononuclear cells in the three tumor types, and those between TRAP-positive multinucleated cells in GCTB and GCTTS, suggest a common cell lineage capable of multinucleated giant cell formation in the 3 tumors, despite differing histogenesis.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalUltrastructural Pathology
Volume30
Issue number3
DOIs
Publication statusPublished - 2006 Jul 1

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Pigmented Villonodular Synovitis
Giant Cell Tumor of Bone
tendons
Tendons
Giant Cells
Stromal Cells
sheaths
bones
Tumors
Bone
tumors
Phosphatases
cells
phosphatases
Acids
Osteoclasts
Neoplasms
Macrophages
acids
Rough Endoplasmic Reticulum

Keywords

  • Giant cell tumor of bone
  • Giant cell tumor of tendon sheath
  • Multinucleated giant cell
  • Pigmented villonodular synovitis
  • Tartrate-resistant acid phosphatase activity
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

Cite this

Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. / Anazawa, Ukei; Hanaoka, Hideya; Shiraishi, Tateru; Morioka, Hideo; Morii, Takeshi; Toyama, Yoshiaki.

In: Ultrastructural Pathology, Vol. 30, No. 3, 01.07.2006, p. 151-158.

Research output: Contribution to journalArticle

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