Simple determination of fluoroquinolones with high-performance liquid chromatography

Hiromi Ogino; Ken'ichi Kido; Masao Tsuchiya; Junko Kizu; Seiji Hori

Simple determination of fluoroquinolones with high-performance liquid chromatography

Hiromi Ogino, Ken'ichi Kido, Masao Tsuchiya, Junko Kizu, Seiji Hori

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.

Original language	English
Pages (from-to)	619-622
Number of pages	4
Journal	Japanese Journal of Chemotherapy
Volume	53
Issue number	10
Publication status	Published - 2005 Oct 1

Keywords

Fluoroquinolone
High performance liquid chromatography

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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AU - Hori, Seiji

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AB - To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.

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KW - High performance liquid chromatography

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Simple determination of fluoroquinolones with high-performance liquid chromatography

Abstract

Keywords

ASJC Scopus subject areas

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