Abstract
To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 619-622 |
| Number of pages | 4 |
| Journal | Japanese Journal of Chemotherapy |
| Volume | 53 |
| Issue number | 10 |
| Publication status | Published - 2005 Oct |
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Keywords
- Fluoroquinolone
- High performance liquid chromatography
ASJC Scopus subject areas
- Pharmacology
Cite this
Simple determination of fluoroquinolones with high-performance liquid chromatography. / Ogino, Hiromi; Kido, Ken'ichi; Tsuchiya, Masao; Kizu, Junko; Hori, Seiji.
In: Japanese Journal of Chemotherapy, Vol. 53, No. 10, 10.2005, p. 619-622.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple determination of fluoroquinolones with high-performance liquid chromatography
AU - Ogino, Hiromi
AU - Kido, Ken'ichi
AU - Tsuchiya, Masao
AU - Kizu, Junko
AU - Hori, Seiji
PY - 2005/10
Y1 - 2005/10
N2 - To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.
AB - To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.
KW - Fluoroquinolone
KW - High performance liquid chromatography
UR - http://www.scopus.com/inward/record.url?scp=28444478465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444478465&partnerID=8YFLogxK
M3 - Article
VL - 53
SP - 619
EP - 622
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 10
ER -