Abstract
To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 619-622 |
| Number of pages | 4 |
| Journal | Japanese Journal of Chemotherapy |
| Volume | 53 |
| Issue number | 10 |
| Publication status | Published - 2005 Oct 1 |
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Keywords
- Fluoroquinolone
- High performance liquid chromatography
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Ogino, H., Kido, K., Tsuchiya, M., Kizu, J., & Hori, S. (2005). Simple determination of fluoroquinolones with high-performance liquid chromatography. Japanese Journal of Chemotherapy, 53(10), 619-622.