Simple determination of fluoroquinolones with high-performance liquid chromatography

Hiromi Ogino, Ken'ichi Kido, Masao Tsuchiya, Junko Kizu, Seiji Hori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.

Original languageEnglish
Pages (from-to)619-622
Number of pages4
JournalJapanese Journal of Chemotherapy
Volume53
Issue number10
Publication statusPublished - 2005 Oct 1

Keywords

  • Fluoroquinolone
  • High performance liquid chromatography

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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