Simple fabrication of Gd(III)-DTPA-nanodiamond particles by chemical modification for use as magnetic resonance imaging (MRI) contrast agent

Takako Nakamura, Tsuguyori Ohana, Hajime Yabuno, Rumiko Kasai, Tetsuya Suzuki, Terumitsu Hasebe

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18 Citations (Scopus)


We have developed a simple and useful process for fabricating nanodiamond (ND) particles modified with an organogadolinium moiety by chemical modification for their use as a magnetic resonance imaging (MRI) contrast agent. The introduction of the organogadolinium moiety on the surface of the ND particles was performed by the condensation of ND and diethylenetriaminepentaacetic acid (DTPA) followed by treatment with GdCl3. The modified surfaces were evaluated by X-ray photoelectron spectroscopy, diffuse reflectance Fourier transform infrared spectroscopy, mass spectroscopy, and inductively coupled plasma atomic emission spectroscopy analyses. MRI experiments on the Gd-DTPAND particles indicated their high signal intensity on T1-weighted images.

Original languageEnglish
Article number015001
JournalApplied Physics Express
Issue number1
Publication statusPublished - 2013 Jan 1


ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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