Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells

Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here, we integrated various characteristics of fetal ventricular cells based on a mathematical model and predicted the contribution of each characteristic to maintenance of intracellular ATP concentration and sarcomere contraction under anoxic conditions. Our simulation results showed that higher glycogen content, higher hexokinase activity, and lower creatine concentration helped to prolong the time that contraction of ventricular cells was maintained under anoxic conditions. The integrated model enabled us to quantitatively assess the contributions of factors related to energy metabolism in ventricular cells.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2016
PublisherIEEE Computer Society
Pages249-252
Number of pages4
Volume43
ISBN (Electronic)9781509008964
Publication statusPublished - 2017 Mar 1
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 2016 Sep 112016 Sep 14

Other

Other43rd Computing in Cardiology Conference, CinC 2016
CountryCanada
CityVancouver
Period16/9/1116/9/14

Fingerprint

Adenosinetriphosphate
Oxidative Phosphorylation
Adenosine Triphosphate
Sarcomeres
Hexokinase
Creatine
Mathematical models
Glycogen
Energy Metabolism
Theoretical Models
Maintenance

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Sano, H. I., Naito, Y., & Tomita, M. (2017). Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells. In Computing in Cardiology Conference, CinC 2016 (Vol. 43, pp. 249-252). [7868726] IEEE Computer Society.

Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells. / Sano, Hitomi I.; Naito, Yasuhiro; Tomita, Masaru.

Computing in Cardiology Conference, CinC 2016. Vol. 43 IEEE Computer Society, 2017. p. 249-252 7868726.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sano, HI, Naito, Y & Tomita, M 2017, Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells. in Computing in Cardiology Conference, CinC 2016. vol. 43, 7868726, IEEE Computer Society, pp. 249-252, 43rd Computing in Cardiology Conference, CinC 2016, Vancouver, Canada, 16/9/11.
Sano HI, Naito Y, Tomita M. Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells. In Computing in Cardiology Conference, CinC 2016. Vol. 43. IEEE Computer Society. 2017. p. 249-252. 7868726
Sano, Hitomi I. ; Naito, Yasuhiro ; Tomita, Masaru. / Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells. Computing in Cardiology Conference, CinC 2016. Vol. 43 IEEE Computer Society, 2017. pp. 249-252
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