Simultaneous crosslinking induces macroscopically phase-separated microgel from a homogeneous mixture of multiple polymers

Yuta Kurashina, Mio Tsuchiya, Atsushi Sakai, Tomoki Maeda, Yun  Jung J. Heo, Filippo Rossi, Nakwon Choi, Miho Yanagisawa, Hiroaki Onoe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

This paper reports a unique phase separation behavior, a simultaneous-crosslinking-driven phase separation in co-gelation (SPSiC) core–shell microgel that spontaneously forms from a homogeneous pre-gel solution of multiple polymers. The SPSiC microgel, composed of an alginate shell and an N-isopropylacrylamide (NIPAM) core, were synthesized by a single fabrication step wherein a mixed pre-gel solution of sodium alginate and NIPAM monomer was ejected by centrifugation with photo-polymerization and ion crosslinking instantaneously. Phase separation was modeled by varying the degree of polymerization and the size of the polymer chain. Moreover, an implantable, multi-functional drug delivery system combined with a transdermal glucose sensor was demonstrated with core–shell Janus SPSiC microgels. This work shows a macroscopic phase separation behavior, which occurs during the gelation process, and also provides a simple and unique methodology to create multifunctional bio-microprobes.

Original languageEnglish
Article number100937
JournalApplied Materials Today
Volume22
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • Biosensor
  • Core–shell structure
  • Hydrogel
  • Microfluidics
  • Phase separation

ASJC Scopus subject areas

  • Materials Science(all)

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