Single center experience of endoscopic submucosal dissection (ESD) in early Barrett´s adenocarcinoma

S. Höbel, P. Dautel, R. Baumbach, K. J. Oldhafer, A. Stang, B. Feyerabend, Naohisa Yahagi, C. Schrader, S. Faiss

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Endoscopic mucosal resection (EMR) or radical surgical resection are the standard treatment options for patients with early Barrett´s adenocarcinoma (EBAC). Endoscopic submucosal dissection (ESD) is a new endoscopic technique, which allows—in contrast to EMR—endoscopic en-bloc resection of neoplastic lesions greater than 2 cm with complete histological evaluation of the resected specimen. In contrast to Western countries, Barrett´s esophagus is less common in Asia indicating the low volume of published data of ESD in EBAC in Japanese series. Therefore, the aim of the present study is to describe the results of ESD in patients with EBAC performed in a German tertiary referral center. Methods: Between November 2009 and April 2014 ESDs were performed in 22 patients with histologically proven EBAC. Data were given for the en-bloc, the R0, the R0 en-bloc, and the curative resection rate as well as for the complication and the local recurrence rate. Results: ESD was technically possible in all of the 22 patients. 20 of the resected EBAC were mucosal carcinomas, whereas in two patients the tumor showed submucosal invasion. The en-bloc, R0, R0 en-bloc, and curative resection rates were 95.5, 81.8, 81.8 %, and77.3 %, resp. Complication rate was 27.3 % (perforation n = 1, bleeding n = 2, stenosis n = 3). In case of curative tumor resection, only one local tumor recurrence (5.9 %) occurred after a medium follow-up of 1.6 years. Conclusions: Despite the small number of patients and a relatively short follow-up, the present data underline the value of ESD, especially in case of curative resections in the definite and less invasive therapy of EBAC. Attention should be drawn toward subsquamous extension of EBAC requiring a sufficient safety margin as an obligate condition for curative R0 resections. Due to the required learning curve and the management of potential complications, ESD should be restricted to greater endoscopic centers.

Original languageEnglish
Pages (from-to)1591-1597
Number of pages7
JournalSurgical Endoscopy and Other Interventional Techniques
Volume29
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Adenocarcinoma
Recurrence
Neoplasms
Learning Curve
Barrett Esophagus
Endoscopic Mucosal Resection
Tertiary Care Centers
Pathologic Constriction
Hemorrhage
Carcinoma
Safety
Therapeutics

Keywords

  • Early Barrett´s carcinoma
  • Endoscopic submucosal dissection
  • Endoscopic tumor resection
  • ESD

ASJC Scopus subject areas

  • Surgery

Cite this

Single center experience of endoscopic submucosal dissection (ESD) in early Barrett´s adenocarcinoma. / Höbel, S.; Dautel, P.; Baumbach, R.; Oldhafer, K. J.; Stang, A.; Feyerabend, B.; Yahagi, Naohisa; Schrader, C.; Faiss, S.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 29, No. 6, 01.06.2015, p. 1591-1597.

Research output: Contribution to journalArticle

Höbel, S, Dautel, P, Baumbach, R, Oldhafer, KJ, Stang, A, Feyerabend, B, Yahagi, N, Schrader, C & Faiss, S 2015, 'Single center experience of endoscopic submucosal dissection (ESD) in early Barrett´s adenocarcinoma', Surgical Endoscopy and Other Interventional Techniques, vol. 29, no. 6, pp. 1591-1597. https://doi.org/10.1007/s00464-014-3847-5
Höbel, S. ; Dautel, P. ; Baumbach, R. ; Oldhafer, K. J. ; Stang, A. ; Feyerabend, B. ; Yahagi, Naohisa ; Schrader, C. ; Faiss, S. / Single center experience of endoscopic submucosal dissection (ESD) in early Barrett´s adenocarcinoma. In: Surgical Endoscopy and Other Interventional Techniques. 2015 ; Vol. 29, No. 6. pp. 1591-1597.
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abstract = "Background: Endoscopic mucosal resection (EMR) or radical surgical resection are the standard treatment options for patients with early Barrett´s adenocarcinoma (EBAC). Endoscopic submucosal dissection (ESD) is a new endoscopic technique, which allows—in contrast to EMR—endoscopic en-bloc resection of neoplastic lesions greater than 2 cm with complete histological evaluation of the resected specimen. In contrast to Western countries, Barrett´s esophagus is less common in Asia indicating the low volume of published data of ESD in EBAC in Japanese series. Therefore, the aim of the present study is to describe the results of ESD in patients with EBAC performed in a German tertiary referral center. Methods: Between November 2009 and April 2014 ESDs were performed in 22 patients with histologically proven EBAC. Data were given for the en-bloc, the R0, the R0 en-bloc, and the curative resection rate as well as for the complication and the local recurrence rate. Results: ESD was technically possible in all of the 22 patients. 20 of the resected EBAC were mucosal carcinomas, whereas in two patients the tumor showed submucosal invasion. The en-bloc, R0, R0 en-bloc, and curative resection rates were 95.5, 81.8, 81.8 {\%}, and77.3 {\%}, resp. Complication rate was 27.3 {\%} (perforation n = 1, bleeding n = 2, stenosis n = 3). In case of curative tumor resection, only one local tumor recurrence (5.9 {\%}) occurred after a medium follow-up of 1.6 years. Conclusions: Despite the small number of patients and a relatively short follow-up, the present data underline the value of ESD, especially in case of curative resections in the definite and less invasive therapy of EBAC. Attention should be drawn toward subsquamous extension of EBAC requiring a sufficient safety margin as an obligate condition for curative R0 resections. Due to the required learning curve and the management of potential complications, ESD should be restricted to greater endoscopic centers.",
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N2 - Background: Endoscopic mucosal resection (EMR) or radical surgical resection are the standard treatment options for patients with early Barrett´s adenocarcinoma (EBAC). Endoscopic submucosal dissection (ESD) is a new endoscopic technique, which allows—in contrast to EMR—endoscopic en-bloc resection of neoplastic lesions greater than 2 cm with complete histological evaluation of the resected specimen. In contrast to Western countries, Barrett´s esophagus is less common in Asia indicating the low volume of published data of ESD in EBAC in Japanese series. Therefore, the aim of the present study is to describe the results of ESD in patients with EBAC performed in a German tertiary referral center. Methods: Between November 2009 and April 2014 ESDs were performed in 22 patients with histologically proven EBAC. Data were given for the en-bloc, the R0, the R0 en-bloc, and the curative resection rate as well as for the complication and the local recurrence rate. Results: ESD was technically possible in all of the 22 patients. 20 of the resected EBAC were mucosal carcinomas, whereas in two patients the tumor showed submucosal invasion. The en-bloc, R0, R0 en-bloc, and curative resection rates were 95.5, 81.8, 81.8 %, and77.3 %, resp. Complication rate was 27.3 % (perforation n = 1, bleeding n = 2, stenosis n = 3). In case of curative tumor resection, only one local tumor recurrence (5.9 %) occurred after a medium follow-up of 1.6 years. Conclusions: Despite the small number of patients and a relatively short follow-up, the present data underline the value of ESD, especially in case of curative resections in the definite and less invasive therapy of EBAC. Attention should be drawn toward subsquamous extension of EBAC requiring a sufficient safety margin as an obligate condition for curative R0 resections. Due to the required learning curve and the management of potential complications, ESD should be restricted to greater endoscopic centers.

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