TY - JOUR
T1 - Single nucleotide polymorphism of interleukin-1β associated with Helicobacter pylori infection in immune thrombocytopenic purpura
AU - Satoh, T.
AU - Pandey, J. P.
AU - Okazaki, Y.
AU - Asahi, A.
AU - Kawakami, Y.
AU - Ikeda, Y.
AU - Kuwana, M.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - To examine the role of genetic factors in development of immune thrombocytopenic purpura (ITP) in association with Helicobacter pylori infection, gene polymorphisms within the loci for human leukocyte antigen class II, interleukin (IL)-1β (-511), tumor necrosis factor-β (+252), immunoglobulin (Ig)G1 heavy chain (+643), and Igκ light chain (+573) were determined in 164 adults with ITP and 75 healthy controls. Of these gene polymorphisms, the IL-1β (-511) T allele was less frequently detected in H. pylori-infected than in H. pylori-uninfected (58% vs 81%, P = 0.01, odds ratio = 0.31) ITP patients diagnosed before age 50. These findings suggest that a single nucleotide polymorphism within the IL-1β (-511) may affect susceptibility to early-onset ITP associated with H. pylori infection.
AB - To examine the role of genetic factors in development of immune thrombocytopenic purpura (ITP) in association with Helicobacter pylori infection, gene polymorphisms within the loci for human leukocyte antigen class II, interleukin (IL)-1β (-511), tumor necrosis factor-β (+252), immunoglobulin (Ig)G1 heavy chain (+643), and Igκ light chain (+573) were determined in 164 adults with ITP and 75 healthy controls. Of these gene polymorphisms, the IL-1β (-511) T allele was less frequently detected in H. pylori-infected than in H. pylori-uninfected (58% vs 81%, P = 0.01, odds ratio = 0.31) ITP patients diagnosed before age 50. These findings suggest that a single nucleotide polymorphism within the IL-1β (-511) may affect susceptibility to early-onset ITP associated with H. pylori infection.
KW - Helicobacter pylori
KW - Immune thrombocytopenic purpura
KW - Infection
KW - Interleukin-1
UR - http://www.scopus.com/inward/record.url?scp=62449126378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62449126378&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0039.2009.01214.x
DO - 10.1111/j.1399-0039.2009.01214.x
M3 - Article
C2 - 19317746
AN - SCOPUS:62449126378
VL - 73
SP - 353
EP - 357
JO - HLA
JF - HLA
SN - 2059-2302
IS - 4
ER -
