Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease

Yoshiaki Itoh, Takahiro Amano, Toshihiko Shimizu, Jun Hashimoto, Atsushi Kubo, Yasuo Fukuuchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 50-year-old woman presented with progressive visual disturbance, ataxia, and dementia. The cerebral cortex became atrophic, as the disease progressed, and electroencephalography showed periodic synchronous discharges. The patient's prion gene revealed a point mutation (232Met to Arg), and a diagnosis of Creutzfeldt-Jakob disease was made. Iomazenil single-photon emission computed tomography (SPECT) was performed to assess neuronal degeneration. Accumulation of the tracer in the late images was severely decreased diffusely spread throughout the cerebral cortex. Our experience with this case suggests that iomazenil SPECT is useful for detecting neuronal degeneration in Creutzfeldt-Jakob disease.

Original languageEnglish
Pages (from-to)896-900
Number of pages5
JournalInternal Medicine
Volume37
Issue number10
Publication statusPublished - 1998

Fingerprint

Creutzfeldt-Jakob Syndrome
GABA-A Receptors
Single-Photon Emission-Computed Tomography
Cerebral Cortex
Prions
Ataxia
Point Mutation
Dementia
Electroencephalography
Genes
iomazenil

Keywords

  • Dementia
  • Iomazenil
  • Prion disease
  • Receptor imaging

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Itoh, Y., Amano, T., Shimizu, T., Hashimoto, J., Kubo, A., & Fukuuchi, Y. (1998). Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease. Internal Medicine, 37(10), 896-900.

Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease. / Itoh, Yoshiaki; Amano, Takahiro; Shimizu, Toshihiko; Hashimoto, Jun; Kubo, Atsushi; Fukuuchi, Yasuo.

In: Internal Medicine, Vol. 37, No. 10, 1998, p. 896-900.

Research output: Contribution to journalArticle

Itoh, Y, Amano, T, Shimizu, T, Hashimoto, J, Kubo, A & Fukuuchi, Y 1998, 'Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease', Internal Medicine, vol. 37, no. 10, pp. 896-900.
Itoh, Yoshiaki ; Amano, Takahiro ; Shimizu, Toshihiko ; Hashimoto, Jun ; Kubo, Atsushi ; Fukuuchi, Yasuo. / Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease. In: Internal Medicine. 1998 ; Vol. 37, No. 10. pp. 896-900.
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