Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation

Incidence, risk factors and outcomes

K. Yakushijin, Y. Atsuta, N. Doki, A. Yokota, H. Kanamori, T. Miyamoto, C. Ohwada, K. Miyamura, Y. Nawa, M. Kurokawa, I. Mizuno, Takehiko Mori, M. Onizuka, J. Taguchi, T. Ichinohe, H. Yabe, Y. Morishima, K. Kato, R. Suzuki, T. Fukuda

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This retrospective study was conducted in Japan to determine the incidence, risk factors and outcomes of sinusoidal obstruction syndrome (SOS) after allogeneic hematopoietic stem cell transplantation (HSCT). Among 4290 patients undergoing allogeneic HSCT between 1999 and 2010, 462 were diagnosed with SOS according to the Seattle criteria (cumulative incidence, 10.8%). The cumulative incidence of SOS diagnosed by the modified Seattle criteria was 9.3%. Of 462 patients, 107 met the Baltimore criteria and 168 had severe SOS with renal and/or respiratory failure. The median onset for SOS was 12 days after HSCT (range, -2-30). Overall survival at day 100 was 32% for SOS and 15% for severe SOS. Multivariate analyses showed that significant independent risk factors for SOS were the number of HSCTs, age, performance status, hepatitis C virus-seropositivity, advanced disease status and myeloablative regimen. SOS was highly associated with overall mortality (hazard ratio, 2.09; P

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalBone Marrow Transplantation
Volume51
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

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Hepatic Veno-Occlusive Disease
Hematopoietic Stem Cell Transplantation
Incidence
Baltimore
Respiratory Insufficiency
Hepacivirus
Renal Insufficiency
Japan
Multivariate Analysis
Retrospective Studies

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation : Incidence, risk factors and outcomes. / Yakushijin, K.; Atsuta, Y.; Doki, N.; Yokota, A.; Kanamori, H.; Miyamoto, T.; Ohwada, C.; Miyamura, K.; Nawa, Y.; Kurokawa, M.; Mizuno, I.; Mori, Takehiko; Onizuka, M.; Taguchi, J.; Ichinohe, T.; Yabe, H.; Morishima, Y.; Kato, K.; Suzuki, R.; Fukuda, T.

In: Bone Marrow Transplantation, Vol. 51, No. 3, 01.03.2016, p. 403-409.

Research output: Contribution to journalArticle

Yakushijin, K, Atsuta, Y, Doki, N, Yokota, A, Kanamori, H, Miyamoto, T, Ohwada, C, Miyamura, K, Nawa, Y, Kurokawa, M, Mizuno, I, Mori, T, Onizuka, M, Taguchi, J, Ichinohe, T, Yabe, H, Morishima, Y, Kato, K, Suzuki, R & Fukuda, T 2016, 'Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: Incidence, risk factors and outcomes', Bone Marrow Transplantation, vol. 51, no. 3, pp. 403-409. https://doi.org/10.1038/bmt.2015.283
Yakushijin, K. ; Atsuta, Y. ; Doki, N. ; Yokota, A. ; Kanamori, H. ; Miyamoto, T. ; Ohwada, C. ; Miyamura, K. ; Nawa, Y. ; Kurokawa, M. ; Mizuno, I. ; Mori, Takehiko ; Onizuka, M. ; Taguchi, J. ; Ichinohe, T. ; Yabe, H. ; Morishima, Y. ; Kato, K. ; Suzuki, R. ; Fukuda, T. / Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation : Incidence, risk factors and outcomes. In: Bone Marrow Transplantation. 2016 ; Vol. 51, No. 3. pp. 403-409.
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AU - Suzuki, R.

AU - Fukuda, T.

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