Abstract
Achievements in site-selective transformations in the field of carbohydrate and flavonoid synthesis are presented in this chapter. In the examples, commercially available lipase-catalyzed acylation and deacylation are especially emphasized. Modification of rate and selectivity by protein engineering of the enzyme catalysts is not discussed in this chapter; instead, the above-mentioned catalytic reactions are elucidated based on reaction conditions such as the solvent and structures of the nucleophiles and substrates. Throughout this chapter, the importance of the choice of the synthetic precursors on the overall synthetic scheme under conditions where the acyl groups are utilized as protective groups is emphasized.
| Original language | English |
|---|---|
| Title of host publication | Future Directions in Biocatalysis |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier |
| Pages | 279-295 |
| Number of pages | 17 |
| ISBN (Print) | 9780444637437 |
| DOIs | |
| Publication status | Published - 2017 Aug 15 |
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Keywords
- Carbohydrate
- Flavonoid
- Lipase
- Polyphenol
- Protective group
- Site-selective acylation
- Site-selective deacylation
ASJC Scopus subject areas
- Engineering(all)
- Chemical Engineering(all)
Cite this
Site-Selective Lipase-Catalyzed Acylation and Deacylation in the Synthesis of Valuable Carbohydrates and Flavonoids From Naturally Abundant Starting Materials. / Tsunekawa, Ryuji; Hanaya, Kengo; Shoji, Mitsuru; Sugai, Takeshi.
Future Directions in Biocatalysis: Second Edition. Elsevier, 2017. p. 279-295.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Site-Selective Lipase-Catalyzed Acylation and Deacylation in the Synthesis of Valuable Carbohydrates and Flavonoids From Naturally Abundant Starting Materials
AU - Tsunekawa, Ryuji
AU - Hanaya, Kengo
AU - Shoji, Mitsuru
AU - Sugai, Takeshi
PY - 2017/8/15
Y1 - 2017/8/15
N2 - Achievements in site-selective transformations in the field of carbohydrate and flavonoid synthesis are presented in this chapter. In the examples, commercially available lipase-catalyzed acylation and deacylation are especially emphasized. Modification of rate and selectivity by protein engineering of the enzyme catalysts is not discussed in this chapter; instead, the above-mentioned catalytic reactions are elucidated based on reaction conditions such as the solvent and structures of the nucleophiles and substrates. Throughout this chapter, the importance of the choice of the synthetic precursors on the overall synthetic scheme under conditions where the acyl groups are utilized as protective groups is emphasized.
AB - Achievements in site-selective transformations in the field of carbohydrate and flavonoid synthesis are presented in this chapter. In the examples, commercially available lipase-catalyzed acylation and deacylation are especially emphasized. Modification of rate and selectivity by protein engineering of the enzyme catalysts is not discussed in this chapter; instead, the above-mentioned catalytic reactions are elucidated based on reaction conditions such as the solvent and structures of the nucleophiles and substrates. Throughout this chapter, the importance of the choice of the synthetic precursors on the overall synthetic scheme under conditions where the acyl groups are utilized as protective groups is emphasized.
KW - Carbohydrate
KW - Flavonoid
KW - Lipase
KW - Polyphenol
KW - Protective group
KW - Site-selective acylation
KW - Site-selective deacylation
UR - http://www.scopus.com/inward/record.url?scp=85067651686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067651686&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-63743-7.00013-5
DO - 10.1016/B978-0-444-63743-7.00013-5
M3 - Chapter
AN - SCOPUS:85067651686
SN - 9780444637437
SP - 279
EP - 295
BT - Future Directions in Biocatalysis
PB - Elsevier
ER -