Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: The importance of orthotopic models to obtain relevant drug evaluation data

T. H. Kuo, T. Kubota, M. Watanabe, T. Furukawa, S. Kase, H. Tanino, Yoshirou Saikawa, K. Ishibiki, M. Kitajima, R. M. Hoffman

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We have developed a novel in vivo model of human small-cell lung carcinoma (SCLC) using orthotopic reconstitution by injecting human SCLC in the tail vein of severe combined immunodeficient (SCID) mice whereby the SCLC grows in the lung and other organs. Cisplatin (DDP) had significant antitumor effects on the SCLC growing orthotopically in the lung whereas mitomycin C (MMC) did not, thereby reflecting the clinical situation. However the opposite effects were found when the SCLC was growing subcutaneously, where the tumors responded to MMC and not to DDP. This suggests that the tumors growing orthotopically reflect the clinical effects of drugs on human SCLC more closely than the tumors growing subcutaneously. Therefore, this orthotopic reconstitution model of human SCLC in SCID mice is thought to be useful for studies on the treatment of human SCLC and emphasizes the need for orthotopic models for relevant cancer drug evaluation.

Original languageEnglish
Pages (from-to)627-630
Number of pages4
JournalAnticancer research
Volume13
Issue number3
Publication statusPublished - 1993 Jan 1

Keywords

  • Human small-cell lung carcinoma
  • Orthotopic transplant
  • SCID mouse
  • Site-specific cancer chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: The importance of orthotopic models to obtain relevant drug evaluation data'. Together they form a unique fingerprint.

  • Cite this