Sites, frequencies, and causes of self-reported fractures in 9,720 rheumatoid arthritis patients: A large prospective observational cohort study in Japan

Kensuke Ochi, Takefumi Furuya, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sites, frequencies, and causes of self-reported fractures in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. The incidence and cause of fracture differ by anatomical site, sex, and age. These differences may be considered in establishing custom strategies for preventing fractures in RA patients in the future. Purpose: The literature contains limited data describing the details of fractures at different skeletal sites in patients with RA. Methods: We evaluated the details of fractures in Japanese RA patients on the basis of our Institute of Rheumatology Rheumatoid Arthritis cohort study in 9,720 RA patients (82 % women; mean age, 56 years) who were enrolled from 2000 to 2010. The details of fractures were obtained through biannual patient self-report questionnaires. Results: Over a mean duration of 5.2 years, 1,317 patients (13.5 %) reported 2,323 incident fractures comprising 563 (24.2 %) clinical vertebral fractures and 1,760 (75.8 %) nonvertebral fractures. Rib fractures were the most common fractures in men, followed by clinical vertebral and hip fractures; the most common fractures in women were clinical vertebral fractures, followed by rib, foot, and hip fractures. There was a significant difference between sexes in the rates of rib, clavicle, shoulder, and ankle fractures. Spontaneous event was the primary cause of clinical vertebral fracture (65.4 %), whereas falls were the primary cause of upper extremity (76.5 %) and lower extremity (57.8 %) fractures. Rates of clinical vertebral and hip fractures increased, while those of rib and foot fractures decreased with increasing age. Incidence of falls, as causes of nonvertebral fractures, also increased in older age groups. Conclusion: Our results suggest that the causes of fractures may differ depending on anatomical site and that prevention of falls may be the most effective way to reduce upper and lower extremity fractures, especially in older patients with RA.

Original languageEnglish
Article number130
JournalArchives of Osteoporosis
Volume8
Issue number1-2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Observational Studies
Rheumatoid Arthritis
Japan
Cohort Studies
Rib Fractures
Hip Fractures
Foot
Lower Extremity
Shoulder Fractures
Ankle Fractures
Clavicle
Incidence
Rheumatology
Upper Extremity
Sex Characteristics
Self Report
Age Groups

Keywords

  • Epidemiology
  • Fall
  • Fracture
  • Japanese
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Sites, frequencies, and causes of self-reported fractures in 9,720 rheumatoid arthritis patients : A large prospective observational cohort study in Japan. / Ochi, Kensuke; Furuya, Takefumi; Ikari, Katsunori; Taniguchi, Atsuo; Yamanaka, Hisashi; Momohara, Shigeki.

In: Archives of Osteoporosis, Vol. 8, No. 1-2, 130, 2013.

Research output: Contribution to journalArticle

Ochi, Kensuke ; Furuya, Takefumi ; Ikari, Katsunori ; Taniguchi, Atsuo ; Yamanaka, Hisashi ; Momohara, Shigeki. / Sites, frequencies, and causes of self-reported fractures in 9,720 rheumatoid arthritis patients : A large prospective observational cohort study in Japan. In: Archives of Osteoporosis. 2013 ; Vol. 8, No. 1-2.
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abstract = "Sites, frequencies, and causes of self-reported fractures in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. The incidence and cause of fracture differ by anatomical site, sex, and age. These differences may be considered in establishing custom strategies for preventing fractures in RA patients in the future. Purpose: The literature contains limited data describing the details of fractures at different skeletal sites in patients with RA. Methods: We evaluated the details of fractures in Japanese RA patients on the basis of our Institute of Rheumatology Rheumatoid Arthritis cohort study in 9,720 RA patients (82 {\%} women; mean age, 56 years) who were enrolled from 2000 to 2010. The details of fractures were obtained through biannual patient self-report questionnaires. Results: Over a mean duration of 5.2 years, 1,317 patients (13.5 {\%}) reported 2,323 incident fractures comprising 563 (24.2 {\%}) clinical vertebral fractures and 1,760 (75.8 {\%}) nonvertebral fractures. Rib fractures were the most common fractures in men, followed by clinical vertebral and hip fractures; the most common fractures in women were clinical vertebral fractures, followed by rib, foot, and hip fractures. There was a significant difference between sexes in the rates of rib, clavicle, shoulder, and ankle fractures. Spontaneous event was the primary cause of clinical vertebral fracture (65.4 {\%}), whereas falls were the primary cause of upper extremity (76.5 {\%}) and lower extremity (57.8 {\%}) fractures. Rates of clinical vertebral and hip fractures increased, while those of rib and foot fractures decreased with increasing age. Incidence of falls, as causes of nonvertebral fractures, also increased in older age groups. Conclusion: Our results suggest that the causes of fractures may differ depending on anatomical site and that prevention of falls may be the most effective way to reduce upper and lower extremity fractures, especially in older patients with RA.",
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T1 - Sites, frequencies, and causes of self-reported fractures in 9,720 rheumatoid arthritis patients

T2 - A large prospective observational cohort study in Japan

AU - Ochi, Kensuke

AU - Furuya, Takefumi

AU - Ikari, Katsunori

AU - Taniguchi, Atsuo

AU - Yamanaka, Hisashi

AU - Momohara, Shigeki

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N2 - Sites, frequencies, and causes of self-reported fractures in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. The incidence and cause of fracture differ by anatomical site, sex, and age. These differences may be considered in establishing custom strategies for preventing fractures in RA patients in the future. Purpose: The literature contains limited data describing the details of fractures at different skeletal sites in patients with RA. Methods: We evaluated the details of fractures in Japanese RA patients on the basis of our Institute of Rheumatology Rheumatoid Arthritis cohort study in 9,720 RA patients (82 % women; mean age, 56 years) who were enrolled from 2000 to 2010. The details of fractures were obtained through biannual patient self-report questionnaires. Results: Over a mean duration of 5.2 years, 1,317 patients (13.5 %) reported 2,323 incident fractures comprising 563 (24.2 %) clinical vertebral fractures and 1,760 (75.8 %) nonvertebral fractures. Rib fractures were the most common fractures in men, followed by clinical vertebral and hip fractures; the most common fractures in women were clinical vertebral fractures, followed by rib, foot, and hip fractures. There was a significant difference between sexes in the rates of rib, clavicle, shoulder, and ankle fractures. Spontaneous event was the primary cause of clinical vertebral fracture (65.4 %), whereas falls were the primary cause of upper extremity (76.5 %) and lower extremity (57.8 %) fractures. Rates of clinical vertebral and hip fractures increased, while those of rib and foot fractures decreased with increasing age. Incidence of falls, as causes of nonvertebral fractures, also increased in older age groups. Conclusion: Our results suggest that the causes of fractures may differ depending on anatomical site and that prevention of falls may be the most effective way to reduce upper and lower extremity fractures, especially in older patients with RA.

AB - Sites, frequencies, and causes of self-reported fractures in Japanese patients with rheumatoid arthritis (RA) were evaluated in a prospective, observational cohort study. The incidence and cause of fracture differ by anatomical site, sex, and age. These differences may be considered in establishing custom strategies for preventing fractures in RA patients in the future. Purpose: The literature contains limited data describing the details of fractures at different skeletal sites in patients with RA. Methods: We evaluated the details of fractures in Japanese RA patients on the basis of our Institute of Rheumatology Rheumatoid Arthritis cohort study in 9,720 RA patients (82 % women; mean age, 56 years) who were enrolled from 2000 to 2010. The details of fractures were obtained through biannual patient self-report questionnaires. Results: Over a mean duration of 5.2 years, 1,317 patients (13.5 %) reported 2,323 incident fractures comprising 563 (24.2 %) clinical vertebral fractures and 1,760 (75.8 %) nonvertebral fractures. Rib fractures were the most common fractures in men, followed by clinical vertebral and hip fractures; the most common fractures in women were clinical vertebral fractures, followed by rib, foot, and hip fractures. There was a significant difference between sexes in the rates of rib, clavicle, shoulder, and ankle fractures. Spontaneous event was the primary cause of clinical vertebral fracture (65.4 %), whereas falls were the primary cause of upper extremity (76.5 %) and lower extremity (57.8 %) fractures. Rates of clinical vertebral and hip fractures increased, while those of rib and foot fractures decreased with increasing age. Incidence of falls, as causes of nonvertebral fractures, also increased in older age groups. Conclusion: Our results suggest that the causes of fractures may differ depending on anatomical site and that prevention of falls may be the most effective way to reduce upper and lower extremity fractures, especially in older patients with RA.

KW - Epidemiology

KW - Fall

KW - Fracture

KW - Japanese

KW - Rheumatoid arthritis

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