Small cell lung cancer with Sjögren's syndrome and Lambert-Eaton myasthenic syndrome

Tomoyasu Nishimura, Sadatomo Tasaka, Wakako Yamasawa, Naoki Hasegawa, Kenzo Soejima, Koichi Sayama, Koichirou Asano, Akitoshi Ishizaka

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Abstract

A 72-year-old man was admitted to our hospital with complaints of dry mouth, muscle weakness of the lower limbs and gait disturbance. The patient had dry mouth, dry eyes, positive anti-SS-B antibody and salivary gland inflammation. Sjögren's syndrome was diagnosed. Since muscle weakness of the lower limbs and gait disturbance were not compatible with Sjögren's syndrome, we considered the possibility of paraneoplastic syndrome. Serum levels of CEA, NSE and ProGRP were elevated. Chest roentgenogram and CT showed a nodular lesion in the right upper lobe of the lung and swollen lymph nodes in the hilum and mediastinum. Small cell lung cancer was diagnosed by bronchoscopy. Anti-P/Q-type Ca2+ channel antibody was positive. Electromyogram showed a reduction in the amplitude of the evoked muscle action potential response after slow repetitive stimulation and did not show a reduction after rapid repetitive stimulation. Based on these findings, we made a diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). Concurrent chemoradiotherapy induced an improvement of muscle weakness of the lower limbs. LEMS is frequently associated with a malignant tumor and an autoimmune disorder. We thought that in this patient, the presentation of LEMS was apparent because he had both Sjögren's syndrome and small cell lung cancer.

Original languageEnglish
Pages (from-to)775-778
Number of pages4
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume44
Issue number10
Publication statusPublished - 2006 Oct

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Lambert-Eaton Myasthenic Syndrome
Muscle Weakness
Small Cell Lung Carcinoma
Lower Extremity
Gait
Mouth
Sialadenitis
Paraneoplastic Syndromes
Mediastinum
Bronchoscopy
Electromyography
Chemoradiotherapy
Action Potentials
Thorax
Lymph Nodes
Muscles
Lung
Antibodies
Serum
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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Small cell lung cancer with Sjögren's syndrome and Lambert-Eaton myasthenic syndrome. / Nishimura, Tomoyasu; Tasaka, Sadatomo; Yamasawa, Wakako; Hasegawa, Naoki; Soejima, Kenzo; Sayama, Koichi; Asano, Koichirou; Ishizaka, Akitoshi.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 44, No. 10, 10.2006, p. 775-778.

Research output: Contribution to journalArticle

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AU - Yamasawa, Wakako

AU - Hasegawa, Naoki

AU - Soejima, Kenzo

AU - Sayama, Koichi

AU - Asano, Koichirou

AU - Ishizaka, Akitoshi

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