Small RNA-Mediated Quiescence of Transposable Elements in Animals

Kuniaki Saito, Mikiko C. Siomi

Research output: Contribution to journalReview article

111 Citations (Scopus)

Abstract

Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

Original languageEnglish
Pages (from-to)687-697
Number of pages11
JournalDevelopmental Cell
Volume19
Issue number5
DOIs
Publication statusPublished - 2010 Nov 16

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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