Small RNA-Mediated Quiescence of Transposable Elements in Animals

Kuniaki Saito, Mikiko C. Siomi

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

Original languageEnglish
Pages (from-to)687-697
Number of pages11
JournalDevelopmental Cell
Volume19
Issue number5
DOIs
Publication statusPublished - 2010 Nov 16

Fingerprint

DNA Transposable Elements
Animals
RNA
Argonaute Proteins
Genetic Fitness
Intergenic DNA
Carisoprodol
Small Interfering RNA
Genes
Genome

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Small RNA-Mediated Quiescence of Transposable Elements in Animals. / Saito, Kuniaki; Siomi, Mikiko C.

In: Developmental Cell, Vol. 19, No. 5, 16.11.2010, p. 687-697.

Research output: Contribution to journalArticle

Saito, Kuniaki ; Siomi, Mikiko C. / Small RNA-Mediated Quiescence of Transposable Elements in Animals. In: Developmental Cell. 2010 ; Vol. 19, No. 5. pp. 687-697.
@article{1097ea782bd14220a15fe241a1554cf9,
title = "Small RNA-Mediated Quiescence of Transposable Elements in Animals",
abstract = "Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.",
author = "Kuniaki Saito and Siomi, {Mikiko C.}",
year = "2010",
month = "11",
day = "16",
doi = "10.1016/j.devcel.2010.10.011",
language = "English",
volume = "19",
pages = "687--697",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Small RNA-Mediated Quiescence of Transposable Elements in Animals

AU - Saito, Kuniaki

AU - Siomi, Mikiko C.

PY - 2010/11/16

Y1 - 2010/11/16

N2 - Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

AB - Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

UR - http://www.scopus.com/inward/record.url?scp=78149476037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149476037&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2010.10.011

DO - 10.1016/j.devcel.2010.10.011

M3 - Article

VL - 19

SP - 687

EP - 697

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 5

ER -