Small RNAs

Artificial piRNAs for transcriptional silencing

Takamasa Hirano, Haruhiko Siomi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Technologies have been developed in animal germ cells that produce artificial piRNAs from transgenes in piRNA clusters to silence target genes by cleaving their transcripts. A new study provides a simple way to generate artificial piRNAs to direct de novo DNA methylation in mice.

Original languageEnglish
Pages (from-to)R280-R283
JournalCurrent Biology
Volume25
Issue number7
DOIs
Publication statusPublished - 2015

Fingerprint

DNA methylation
DNA Methylation
Transgenes
Germ Cells
Small Interfering RNA
transgenes
germ cells
Animals
Genes
Cells
RNA
Technology
mice
animals
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Small RNAs : Artificial piRNAs for transcriptional silencing. / Hirano, Takamasa; Siomi, Haruhiko.

In: Current Biology, Vol. 25, No. 7, 2015, p. R280-R283.

Research output: Contribution to journalArticle

Hirano, Takamasa ; Siomi, Haruhiko. / Small RNAs : Artificial piRNAs for transcriptional silencing. In: Current Biology. 2015 ; Vol. 25, No. 7. pp. R280-R283.
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