Smart latexes for bioseparation

Haruma Kawaguchi, Keiji Fujimoto

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Monodisperse, thermosensitive microspheres with sub-micron diameters are used for separation and collection of proteins and other biomolecules. The thermosensitivity gives the microspheres two valuable features. One is the controllability of affinity between microsphere and protein with temperature. The quality and quantity of proteins to be adsorbed on the microspheres can be controlled with temperature. The other feature is reversible control of dispersion stability. Microspheres which have adsorbed target proteins in the dispersion can be easily recovered by changing temperature.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
Issue number4-5
Publication statusPublished - 1998


  • Coagulation
  • Hydrophilicity
  • Latex
  • Microsphere
  • Thermosensitive polymer

ASJC Scopus subject areas

  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Chemical Engineering(all)


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