Smart latexes for bioseparation

Haruma Kawaguchi, Keiji Fujimoto

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

Monodisperse, thermosensitive microspheres with sub-micron diameters are used for separation and collection of proteins and other biomolecules. The thermosensitivity gives the microspheres two valuable features. One is the controllability of affinity between microsphere and protein with temperature. The quality and quantity of proteins to be adsorbed on the microspheres can be controlled with temperature. The other feature is reversible control of dispersion stability. Microspheres which have adsorbed target proteins in the dispersion can be easily recovered by changing temperature.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalBioseparation
Volume7
Issue number4-5
DOIs
Publication statusPublished - 1998

Keywords

  • Coagulation
  • Hydrophilicity
  • Latex
  • Microsphere
  • Thermosensitive polymer

ASJC Scopus subject areas

  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Chemical Engineering(all)

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