Smooth isoindolinone formation from isopropyl carbamates via bischler-napieralski-type cyclization

Satoshi Adachi, Masao Onozuka, Yuko Yoshida, Mitsuaki Ide, Yoko Saikawa, Masaya Nakata

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalOrganic Letters
Volume16
Issue number2
DOIs
Publication statusPublished - 2014 Mar 17

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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