SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

Yan Hui Fan; You Qiang Song; Danny Chan; Yohei Takahashi; Shiro Ikegawa; Morio Matsumoto; Ikuyo Kou; Kathryn S.E. Cheah; Pak Sham; Kenneth M.C. Cheung; Keith D.K. Luk

doi:10.1038/jhg.2012.11

SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

Yan Hui Fan, You Qiang Song, Danny Chan, Yohei Takahashi, Shiro Ikegawa, Morio Matsumoto, Ikuyo Kou, Kathryn S.E. Cheah, Pak Sham, Kenneth M.C. Cheung, Keith D.K. Luk

Department of Orthopaedics

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10^-10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.

Original language	English
Pages (from-to)	244-246
Number of pages	3
Journal	Journal of Human Genetics
Volume	57
Issue number	4
DOIs	https://doi.org/10.1038/jhg.2012.11
Publication status	Published - 2012 Apr

Keywords

adolescent idiopathic scoliosis
replication study
rs11190870
southern Chinese

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1038/jhg.2012.11

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title = "SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese",

abstract = "A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10-10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.",

keywords = "adolescent idiopathic scoliosis, replication study, rs11190870, southern Chinese",

author = "Fan, {Yan Hui} and Song, {You Qiang} and Danny Chan and Yohei Takahashi and Shiro Ikegawa and Morio Matsumoto and Ikuyo Kou and Cheah, {Kathryn S.E.} and Pak Sham and Cheung, {Kenneth M.C.} and Luk, {Keith D.K.}",

year = "2012",

month = apr,

doi = "10.1038/jhg.2012.11",

language = "English",

volume = "57",

pages = "244--246",

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issn = "1434-5161",

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T1 - SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

AU - Fan, Yan Hui

AU - Song, You Qiang

AU - Chan, Danny

AU - Takahashi, Yohei

AU - Ikegawa, Shiro

AU - Matsumoto, Morio

AU - Kou, Ikuyo

AU - Cheah, Kathryn S.E.

AU - Sham, Pak

AU - Cheung, Kenneth M.C.

AU - Luk, Keith D.K.

PY - 2012/4

Y1 - 2012/4

N2 - A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10-10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.

AB - A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10-10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.

KW - adolescent idiopathic scoliosis

KW - replication study

KW - rs11190870

KW - southern Chinese

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SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

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Keywords

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