SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

Yan Hui Fan, You Qiang Song, Danny Chan, Yohei Takahashi, Shiro Ikegawa, Morio Matsumoto, Ikuyo Kou, Kathryn S.E. Cheah, Pak Sham, Kenneth M.C. Cheung, Keith D.K. Luk

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Abstract

A study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10-10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS.

Original languageEnglish
Pages (from-to)244-246
Number of pages3
JournalJournal of Human Genetics
Volume57
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Keywords

  • adolescent idiopathic scoliosis
  • replication study
  • rs11190870
  • southern Chinese

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Fan, Y. H., Song, Y. Q., Chan, D., Takahashi, Y., Ikegawa, S., Matsumoto, M., Kou, I., Cheah, K. S. E., Sham, P., Cheung, K. M. C., & Luk, K. D. K. (2012). SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. Journal of Human Genetics, 57(4), 244-246. https://doi.org/10.1038/jhg.2012.11