SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

Hiroyuki Unoki, Atsushi Takahashi, Takahisa Kawaguchi, Kazuo Hara, Momoko Horikoshi, Gitte Andersen, Daniel P.K. Ng, Johan Holmkvist, Knut Borch-Johnsen, Torben Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Torben Hansen, Siti Nurbaya, Tatsuhiko Tsunoda, Michiaki Kubo, Tetsuya Babazono, Hiroshi Hirose, Matsuhiko Hayashi, Yasuhiko IwamotoAtsunori Kashiwagi, Kohei Kaku, Ryuzo Kawamori, E. Shyong Tai, Oluf Pedersen, Naoyuki Kamatani, Takashi Kadowaki, Ryuichi Kikkawa, Yusuke Nakamura, Shiro Maeda

Research output: Contribution to journalArticlepeer-review

528 Citations (Scopus)

Abstract

We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 × 10 -12; OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 × 10-9; OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 × 10-13; OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 × 10 -3; OR = 1.14, rs2237897, P = 2.4 × 10-4; OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 × 10 -11; OR = 1.24, rs2237897, P = 1.2 × 10-4; OR = 1.36).

Original languageEnglish
Pages (from-to)1098-1102
Number of pages5
JournalNature genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 2008 Sep

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations'. Together they form a unique fingerprint.

Cite this