SOCS genes

Critical regulators of cytokine signaling and immune responses

Akihiko Yoshimura, Hitomi Nishinakamura, Hiromi Takaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. Many of these cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. We investigated the roles of suppressors of cytokine signaling (SOCSs) in regulating dendritic cell (DC) maturation and function. We showed that SOCS1-deficient DCs induced stronger Th1-type responses both in vitro and in vivo. SOCS1-deficient DCs induced higher interferon-γ (IFNγ) production from naive T cells than wild-type DCs in vitro. Lymph node T cells also produced higher amount of IFNγ when SOCS1-deficient bone marrow-derived (BM) DCs were transferred in vivo. Moreover, SOCS1-/- BMDCs raised more effective anti-tumor immunity than wild-type BMDCs. On the other hand, SOCS3-deficeint BMDCs expressed lower levels of MHC, co-stimulators and CD40 in response to LPS. SOCS3-deficient DCs induced lower T cell responses. Thus, SOCS1 and SOCS3 reciprocally regulate DC maturation.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalInternational Congress Series
Volume1285
DOIs
Publication statusPublished - 2005 Nov
Externally publishedYes

Fingerprint

Regulator Genes
Cytokines
Interferons
T-Lymphocytes
Dendritic Cells
Suppressor of Cytokine Signaling Proteins
STAT Transcription Factors
Janus Kinases
Interleukins
Adaptive Immunity
Innate Immunity
Protein-Tyrosine Kinases
Immune System
Immunity
Homeostasis
Lymph Nodes
Bone Marrow
Neoplasms
Proteins
In Vitro Techniques

Keywords

  • Cytokine
  • NF-κB
  • STAT
  • Toll-like receptor (TLR) family
  • Tyrosine kinase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

SOCS genes : Critical regulators of cytokine signaling and immune responses. / Yoshimura, Akihiko; Nishinakamura, Hitomi; Takaki, Hiromi.

In: International Congress Series, Vol. 1285, 11.2005, p. 121-129.

Research output: Contribution to journalArticle

Yoshimura, Akihiko ; Nishinakamura, Hitomi ; Takaki, Hiromi. / SOCS genes : Critical regulators of cytokine signaling and immune responses. In: International Congress Series. 2005 ; Vol. 1285. pp. 121-129.
@article{091c5dfd544c4890bfb7a884cf7d779a,
title = "SOCS genes: Critical regulators of cytokine signaling and immune responses",
abstract = "Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. Many of these cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. We investigated the roles of suppressors of cytokine signaling (SOCSs) in regulating dendritic cell (DC) maturation and function. We showed that SOCS1-deficient DCs induced stronger Th1-type responses both in vitro and in vivo. SOCS1-deficient DCs induced higher interferon-γ (IFNγ) production from naive T cells than wild-type DCs in vitro. Lymph node T cells also produced higher amount of IFNγ when SOCS1-deficient bone marrow-derived (BM) DCs were transferred in vivo. Moreover, SOCS1-/- BMDCs raised more effective anti-tumor immunity than wild-type BMDCs. On the other hand, SOCS3-deficeint BMDCs expressed lower levels of MHC, co-stimulators and CD40 in response to LPS. SOCS3-deficient DCs induced lower T cell responses. Thus, SOCS1 and SOCS3 reciprocally regulate DC maturation.",
keywords = "Cytokine, NF-κB, STAT, Toll-like receptor (TLR) family, Tyrosine kinase",
author = "Akihiko Yoshimura and Hitomi Nishinakamura and Hiromi Takaki",
year = "2005",
month = "11",
doi = "10.1016/j.ics.2005.07.028",
language = "English",
volume = "1285",
pages = "121--129",
journal = "International Congress Series",
issn = "0531-5131",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - SOCS genes

T2 - Critical regulators of cytokine signaling and immune responses

AU - Yoshimura, Akihiko

AU - Nishinakamura, Hitomi

AU - Takaki, Hiromi

PY - 2005/11

Y1 - 2005/11

N2 - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. Many of these cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. We investigated the roles of suppressors of cytokine signaling (SOCSs) in regulating dendritic cell (DC) maturation and function. We showed that SOCS1-deficient DCs induced stronger Th1-type responses both in vitro and in vivo. SOCS1-deficient DCs induced higher interferon-γ (IFNγ) production from naive T cells than wild-type DCs in vitro. Lymph node T cells also produced higher amount of IFNγ when SOCS1-deficient bone marrow-derived (BM) DCs were transferred in vivo. Moreover, SOCS1-/- BMDCs raised more effective anti-tumor immunity than wild-type BMDCs. On the other hand, SOCS3-deficeint BMDCs expressed lower levels of MHC, co-stimulators and CD40 in response to LPS. SOCS3-deficient DCs induced lower T cell responses. Thus, SOCS1 and SOCS3 reciprocally regulate DC maturation.

AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. Many of these cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. We investigated the roles of suppressors of cytokine signaling (SOCSs) in regulating dendritic cell (DC) maturation and function. We showed that SOCS1-deficient DCs induced stronger Th1-type responses both in vitro and in vivo. SOCS1-deficient DCs induced higher interferon-γ (IFNγ) production from naive T cells than wild-type DCs in vitro. Lymph node T cells also produced higher amount of IFNγ when SOCS1-deficient bone marrow-derived (BM) DCs were transferred in vivo. Moreover, SOCS1-/- BMDCs raised more effective anti-tumor immunity than wild-type BMDCs. On the other hand, SOCS3-deficeint BMDCs expressed lower levels of MHC, co-stimulators and CD40 in response to LPS. SOCS3-deficient DCs induced lower T cell responses. Thus, SOCS1 and SOCS3 reciprocally regulate DC maturation.

KW - Cytokine

KW - NF-κB

KW - STAT

KW - Toll-like receptor (TLR) family

KW - Tyrosine kinase

UR - http://www.scopus.com/inward/record.url?scp=33646447849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646447849&partnerID=8YFLogxK

U2 - 10.1016/j.ics.2005.07.028

DO - 10.1016/j.ics.2005.07.028

M3 - Article

VL - 1285

SP - 121

EP - 129

JO - International Congress Series

JF - International Congress Series

SN - 0531-5131

ER -