SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

Jean Christophe Marine, David J. Topham, Catriona McKay, Demin Wang, Evan Parganas, Dimitrios Stravopodis, Akihiko Yoshimura, James N. Ihle

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks. During this period thymic changes include a loss of cellularity and a switch from predominantly CD4+CD8+ to single positive cells. Peripheral T cells express activation antigens and proliferate to IL-2 in the absence of anti-CD3. In addition, IFNγ, is present in the serum. Reconstitution of the lymphoid lineage of JAK3-deficient mice with SOCS1-deficient stem cells recapitulates the lethality and T cell alterations. Introducing a RAG2 or IFNγ, deficiency eliminates lethality. The results demonstrate that lymphocytes are critical to SOCS1-associated perinatal lethality and implicate SOCS1 in lymphocyte differentiation or regulation.

Original languageEnglish
Pages (from-to)609-616
Number of pages8
JournalCell
Volume98
Issue number5
DOIs
Publication statusPublished - 1999 Sep 3
Externally publishedYes

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T-cells
Lymphocytes
CD27 Antigens
Thymocytes
Stem cells
Interleukin-2
Stem Cells
Chemical activation
Cells
Switches
T-Lymphocytes
Antigens
Serum
Proteins
Mouse Il27ra protein

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Marine, J. C., Topham, D. J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., ... Ihle, J. N. (1999). SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell, 98(5), 609-616. https://doi.org/10.1016/S0092-8674(00)80048-3

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. / Marine, Jean Christophe; Topham, David J.; McKay, Catriona; Wang, Demin; Parganas, Evan; Stravopodis, Dimitrios; Yoshimura, Akihiko; Ihle, James N.

In: Cell, Vol. 98, No. 5, 03.09.1999, p. 609-616.

Research output: Contribution to journalArticle

Marine, JC, Topham, DJ, McKay, C, Wang, D, Parganas, E, Stravopodis, D, Yoshimura, A & Ihle, JN 1999, 'SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality', Cell, vol. 98, no. 5, pp. 609-616. https://doi.org/10.1016/S0092-8674(00)80048-3
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 1999 Sep 3;98(5):609-616. https://doi.org/10.1016/S0092-8674(00)80048-3
Marine, Jean Christophe ; Topham, David J. ; McKay, Catriona ; Wang, Demin ; Parganas, Evan ; Stravopodis, Dimitrios ; Yoshimura, Akihiko ; Ihle, James N. / SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. In: Cell. 1999 ; Vol. 98, No. 5. pp. 609-616.
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