SOCS3 is essential in the regulation of fetal liver erythropoiesis

Jean Christophe Marine; Catriona McKay; Demin Wang; David J. Topham; Evan Parganas; Hideaki Nakajima; Hélène Pendeville; Hideo Yasukawa; Atsuo Sasaki; Akihiko Yoshimura; James N. Ihle

doi:10.1016/S0092-8674(00)80049-5

SOCS3 is essential in the regulation of fetal liver erythropoiesis

Jean Christophe Marine, Catriona McKay, Demin Wang, David J. Topham, Evan Parganas, Hideaki Nakajima, Hélène Pendeville, Hideo Yasukawa, Atsuo Sasaki, Akihiko Yoshimura, James N. Ihle

Department of Internal Medicine

Research output: Contribution to journal › Article

296 Citations (Scopus)

Abstract

SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene- mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.

Original language	English
Pages (from-to)	617-627
Number of pages	11
Journal	Cell
Volume	98
Issue number	5
DOIs	https://doi.org/10.1016/S0092-8674(00)80049-5
Publication status	Published - 1999 Sep 3

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/S0092-8674(00)80049-5

Fingerprint Dive into the research topics of 'SOCS3 is essential in the regulation of fetal liver erythropoiesis'. Together they form a unique fingerprint.

Cite this

Marine, J. C., McKay, C., Wang, D., Topham, D. J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., & Ihle, J. N. (1999). SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell, 98(5), 617-627. https://doi.org/10.1016/S0092-8674(00)80049-5

@article{f6b434c947a041ba97f484f09936c4f8,

title = "SOCS3 is essential in the regulation of fetal liver erythropoiesis",

abstract = "SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene- mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.",

author = "Marine, {Jean Christophe} and Catriona McKay and Demin Wang and Topham, {David J.} and Evan Parganas and Hideaki Nakajima and H{\'e}l{\`e}ne Pendeville and Hideo Yasukawa and Atsuo Sasaki and Akihiko Yoshimura and Ihle, {James N.}",

year = "1999",

month = sep,

day = "3",

doi = "10.1016/S0092-8674(00)80049-5",

language = "English",

volume = "98",

pages = "617--627",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - SOCS3 is essential in the regulation of fetal liver erythropoiesis

AU - Marine, Jean Christophe

AU - McKay, Catriona

AU - Wang, Demin

AU - Topham, David J.

AU - Parganas, Evan

AU - Nakajima, Hideaki

AU - Pendeville, Hélène

AU - Yasukawa, Hideo

AU - Sasaki, Atsuo

AU - Yoshimura, Akihiko

AU - Ihle, James N.

PY - 1999/9/3

Y1 - 1999/9/3

N2 - SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene- mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.

AB - SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene- mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in an embryonic lethality at 12-16 days associated with marked erythrocytosis. Moreover, the in vitro proliferative capacity of progenitors is greatly increased. SOCS3-deficient fetal liver stem cells can reconstitute hematopoiesis in lethally irradiated adults, indicating that its absence does not disturb bone marrow erythropoiesis. Reconstitution of lymphoid lineages in JAK3-deficient mice also occurs normally. The results demonstrate that SOCS3 is critical in negatively regulating fetal liver hematopoiesis.

UR - http://www.scopus.com/inward/record.url?scp=0033520389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033520389&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(00)80049-5

DO - 10.1016/S0092-8674(00)80049-5

M3 - Article

C2 - 10490101

AN - SCOPUS:0033520389

VL - 98

SP - 617

EP - 627

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -